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Annu Int Conf IEEE Eng Med Biol Soc

Title:		Roles of regulated internalization in the polarization of cell surface receptors
Author(s):		Tian W; Cao Y; Ismael A; Stone D; Liang J;
Address:
Journal Title:		Annu Int Conf IEEE Eng Med Biol Soc
Year:		2014
Volume:		2014
Issue:
Page Number:		1166 - 1169
DOI:		10.1109/EMBC.2014.6943803
ISSN/ISBN:		2694-0604 (Electronic) 1557-170X (Print) 2375-7477 (Linking)
Abstract:		"Cell polarization, the generation of cellular asymmetries, is a fundamental biological process. Polarity of different molecules can arise through several mechanisms. Among these, internalization has been shown to play an important role in the polarization of cell surface receptors. The internalization of cell surface receptors can be upregulated upon ligand binding. Additional regulatory mechanism can downregulate the internalization process. Here we describe a general model, which incorporates these two opposing processes, to study the role of internalization in the establishment of cell polarity. We find that the competition between these two processes is sufficient to induce receptor polarization. Our results show that regulated internalization provides additional regulation on polarization as well. In addition, we discuss applications of our model to the yeast system, which shows the capability and potential of the model"
Keywords:		"*Cell Polarity/drug effects *Endocytosis/drug effects Ligands Models, Biological Pheromones/pharmacology Receptors, Cell Surface/*metabolism Receptors, Pheromone/metabolism Saccharomyces cerevisiae/*cytology/drug effects/*metabolism Saccharomyces cerevisi;"
Notes:		"MedlineTian, Wei Cao, Youfang Ismael, Amber Stone, David Liang, Jie eng P50 GM086145/GM/NIGMS NIH HHS/ R01 GM079804/GM/NIGMS NIH HHS/ GM079804/GM/NIGMS NIH HHS/ GM086145/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. 2015/01/09 Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:1166-9. doi: 10.1109/EMBC.2014.6943803"