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Biochem Biophys Rep

Title:		Salivary beta-glucosidase as a direct factor influencing the occurrence of halitosis
Author(s):		Teixeira Essenfelder L; Gomes AA; Coimbra JLM; Moreira MA; Ferraz SM; Miquelluti DJ; Felippe da Silva G; Magalhaes MLB;
Address:		"Biochemistry Laboratory, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina, 88520-000, Brazil. Department of Soil and Natural Resources, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina, 88520-000, Brazil. Department of Veterinary Medicine, Center of Agroveterinary Sciences, State University of Santa Catarina, Lages, Santa Catarina, 88520-000, Brazil"
Journal Title:		Biochem Biophys Rep
Year:		2021
Volume:		20210306
Issue:
Page Number:		100965 -
DOI:		10.1016/j.bbrep.2021.100965
ISSN/ISBN:		2405-5808 (Electronic) 2405-5808 (Linking)
Abstract:		"beta-Glucosidases are enzymes present in all living organisms, playing a pivotal role in diverse biological processes. These enzymes cleave beta-glycosidic bonds between carbohydrates, or between a carbohydrate and a non-carbohydrate moiety, which may result in the liberation of volatile aglycones. Released compounds execute diverse physiological roles, while the industry takes advantage of exogenously added beta-glucosidases for aroma enrichment during food and beverage production. beta-Glucosidase enzymatic activity has been reported in human saliva and given the fact that these enzymes are involved in aroma release, we investigated here the correlation between beta-glucosidase activity in human saliva and the occurrence of halitosis. Measurement of salivary enzyme activity of 48 volunteers was performed using p-nitrophenyl-beta-d-glucopyranoside as substrate. Each volunteer was clinically evaluated by a dental surgeon and clinical and laboratorial data were statistically analyzed. Gas-chromatography of saliva headspace allowed the analysis of the direct role of exogenous beta-glucosidase on aromatic /volatile profile of saliva samples. The data demonstrated a positive correlation between halitosis and enzymatic activity, suggesting that the enzyme exerts a direct role in the occurrence of bad breath. Gas-chromatography analysis demonstrated that exogenously added enzyme led to the alteration of volatile organic content, confirming a direct contribution of beta-glucosidase activity on saliva volatile compounds release. Although halitosis is a multifactorial condition, the complete understanding of all governing factors may allow the development of more effective treatment strategies. Such studies may pave the way to the use of beta-glucosidase inhibitors for halitosis clinical management"
Keywords:		Biofilm Halitosis Oral health Saliva beta-Glucosidase;
Notes:		"PubMed-not-MEDLINETeixeira Essenfelder, Lucimari Gomes, Anderson Albino Coimbra, Jefferson Luis Meirelles Moreira, Marcelo Alves Ferraz, Sandra Maria Miquelluti, David Jose Felippe da Silva, Gustavo Magalhaes, Maria de Lourdes Borba eng Netherlands 2021/03/19 Biochem Biophys Rep. 2021 Mar 6; 26:100965. doi: 10.1016/j.bbrep.2021.100965. eCollection 2021 Jul"