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Sex Med

Title:		Olfactory Exposure to beta-Caryophyllene Increases Testosterone Levels in Women's Saliva
Author(s):		Tarumi W; Shinohara K;
Address:		"Division of Neurobiology and Behavior Department of Translational Medical Sciences Course of Medical and Dental Sciences Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan. Division of Neurobiology and Behavior Department of Translational Medical Sciences Course of Medical and Dental Sciences Nagasaki University, Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: nagasakiphysiol2@gmail.com"
Journal Title:		Sex Med
Year:		2020
Volume:		20200616
Issue:		3
Page Number:		525 - 531
DOI:		10.1016/j.esxm.2020.06.001
ISSN/ISBN:		2050-1161 (Print) 2050-1161 (Electronic) 2050-1161 (Linking)
Abstract:		"INTRODUCTION: From previous studies, we hypothesized that olfactory exposure to beta-caryophyllene stimulates women's libido. However, Japan's sex culture is so closed that it is difficult to test this possibility without accumulating scientific evidence. Therefore, it is necessary to measure the concentration of sex-related hormones in saliva, an experimental technique that is relatively easy to obtain research permission, and to obtain a scientific basis to convince ethics committee reviewers. AIM: The aim of this study is to investigate whether beta-caryophyllene increases salivary testosterone concentrations associated with libido and vaginal sensation during intercourse in women. METHODS: 19 women in the follicular phase of the menstrual cycle participated in the study. The subjects then sat in front of the odor exposure device we had created. Each subject was exposed to dipropylene glycol for 20 minutes, followed by 3% beta-caryophyllene for 20 minutes. Saliva was collected 4 times: before and after control exposure, and before and after beta-caryophyllene exposure. MAIN OUTCOME MEASURE: Salivary testosterone and estrogen concentrations were measured with a competition ELISA. RESULTS: beta-caryophyllene significantly increased the salivary concentration of testosterone (control vs beta-caryophyllene; 0.97 +/- 0.05 vs 1.13 +/- 0.03, P = .00, 95% confidence interval of control: 0.84-1.09, 95% confidence interval of beta-caryophyllene: 1.04-1.20) but not estrogen (control vs beta-caryophyllene; 1.05 +/- 0.03 vs 1.07 +/- 0.04, P = .69, 95% confidence interval of control: 0.96-1.12, 95% confidence interval of beta-caryophyllene: 0.98-1.15). STRENGTHS & LIMITATIONS: The personal preferences of the subjects and the order of exposure may have affected the results. CONCLUSION: beta-caryophyllene may be a remedy with fewer side effects for women with decreased libido. We believe that beta-caryophyllene may be a remedy for women with decreased libido. However, this hypothesis must be tested by further clinical studies. Wataru Tarumi, Kazuyuki Shinohara. Olfactory Exposure to beta-Caryophyllene Increases Testosterone Levels in Women's Saliva. J Sex Med 2020;8:525-531"
Keywords:		Aphrodisiac Pheromone Sexuality Testosterone Ylang-ylang beta-caryophyllene;
Notes:		"PubMed-not-MEDLINETarumi, Wataru Shinohara, Kazuyuki eng England 2020/06/21 Sex Med. 2020 Sep; 8(3):525-531. doi: 10.1016/j.esxm.2020.06.001. Epub 2020 Jun 16"