| Title: | Squalene is a potential endocrine modulator in rat: A proof-of-principle study with 3-methylcholanthrene-induced toxicity |
| Author(s): | Suriyakalaa U; Ramachandran R; Usha K; Sankarganesh D; Praveenkumar D; Abinaya S; Tirupathi Pichiah PB; Kamalakkannan S; Achiraman S; |
| Address: | "Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli, Tamilnadu, India. Department of Microbial Biotechnology, Bharathiar University, Coimbatore, Tamilnadu, India. Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research & Education, Krishnankoil, Tamilnadu, India. Department of Zoology, Bishop Heber College, Tiruchirappalli, Tamilnadu, India" |
| ISSN/ISBN: | 1439-0272 (Electronic) 0303-4569 (Linking) |
| Abstract: | "Oestrus urine was proved as a potential endocrine modulator in alleviating the toxicity induced by 3-methylcholanthrene (3-MC) in male rats. We, in this study, aimed to prove the attributing potential of toxicity alleviation to squalene, an oestrus-specific pheromone in rats. A single dose of 3-methylcholanthrene (25 mg/kg BW, i.p.) was administered to male Wistar rats with concurrent exposure to squalene sprayed in bedding material (Group III). Group II rats did receive 3-MC treatment but did not expose to squalene. Group I rats were intact control neither administered 3-MC nor sprayed with squalene. In consequence of 3-MC toxicity, liver and testes weights were increased and the components of blood cells (RBC and WBC count, Hb level) and testosterone concentration were significantly reduced in Group II rats. Moreover, sperm count was reduced and antioxidants (testes and epididymis) were significantly altered. Exposure to squalene in Group III rats comparatively normalised all the variable components towards baseline and reorganised the histological architecture of reproductive tissues that were exacerbated with 3-MC toxicity. This study ultimately proved squalene as a potent molecule in alleviating the toxicity induced by 3-methylcholanthrene" |
| Keywords: | "Animals Blood Cell Count Endocrine Disruptors/*toxicity Environmental Pollutants/*toxicity Epididymis/drug effects Liver/drug effects Male Methylcholanthrene/toxicity Models, Animal Rats Rats, Wistar Sex Attractants/*pharmacology Sperm Count Squalene/*pha;" |
| Notes: | "MedlineSuriyakalaa, Udhayaraj Ramachandran, Rajamanickam Usha, Karuppiah Sankarganesh, Devaraj Praveenkumar, Dharmaraj Abinaya, Subramanian Tirupathi Pichiah, Pichiah Balasubramanian Kamalakkannan, Soundararajan Achiraman, Shanmugam eng UGC-36-54/2008/University Grants Commission/ DST-FAST TRACK-SR/FT/LS-147, 2009/Department of Science and Technology/ CSIR-23 (0017/10/EMR-II), 2010/Council of Scientific and Industrial Research/ Germany 2018/08/08 Andrologia. 2018 Dec; 50(10):e13117. doi: 10.1111/and.13117. Epub 2018 Aug 7" |
