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Pediatr Pulmonol

Title:		Relationship between lung function and exhaled volatile organic compounds in healthy infants
Author(s):		Sola-Martinez RA; Sanchez-Solis M; Lozano-Terol G; Gallego-Jara J; Garcia-Marcos L; Canovas Diaz M; de Diego Puente T; Group NS;
Address:		"Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. Group of Molecular Systems Biology, Biomedical Research Institute of Murcia, IMIB-Arrixaca, Murcia, Spain. Group of Pediatric Research, Biomedical Research Institute of Murcia, IMIB-Arrixaca, Murcia, Spain. Respiratory and Allergy Units, Arrixaca Children's University Hospital, University of Murcia, Murcia, Spain. Network of Asthma and Adverse and Allergy Reactions (ARADyAL), Health Institute Carlos III, Madrid, Spain"
Journal Title:		Pediatr Pulmonol
Year:		2022
Volume:		20220207
Issue:		5
Page Number:		1282 - 1292
DOI:		10.1002/ppul.25849
ISSN/ISBN:		1099-0496 (Electronic) 8755-6863 (Print) 1099-0496 (Linking)
Abstract:		"OBJECTIVE: The aim of this study is to assess, for the first time, the relationship between the volatilome and lung function in healthy infants, which may be of help for the early detection of certain respiratory diseases. Lung function tests are crucial in chronic respiratory diseases diagnosis. Moreover, volatile organic compounds (VOCs) analysis in exhaled breath is a noninvasive technique that enables the monitorization of oxidative stress, typical of some forms of airway inflammation. METHODS: Lung function was studied in 50 healthy infants of 3-8 months of age and the following parameters were obtained: forced vital capacity (FVC), forced expiratory volume at 0.5 s (FEV(0.5) ), forced expiratory flow at 75% of FVC (FEF(75) ), forced expiratory flow at 25%-75% of FVC (FEF(25-75) ), and FEV(0.5) /FVC. Lung function was measured according to the raised volume rapid thoracoabdominal compression technique. In addition, a targeted analysis of six endogenous VOCs (acetone, isoprene, decane, undecane, tetradecane, and pentadecane) in the exhaled breath of the children was carried out by means of thermal desorption coupled gas chromatography-single quadrupole mass spectrometry system. RESULTS: A negatively significant relationship has been observed between levels of acetone, tetradecane, and pentadecane in exhaled breath and several of the lung function parameters. Levels of acetone (feature m/z = 58) were significantly negatively associated with FVC and FVE(0.5) , levels of tetradecane (feature m/z = 71) with FEV(0.5,) and levels of pentadecane (feature m/z = 71) with FEV(0.5) and FEF(25-75) . CONCLUSION: The findings of this study highlight a significant association between VOCs related to oxidative stress and lung function in healthy infants"
Keywords:		Acetone Breath Tests Child Forced Expiratory Volume Humans Infant Lung Vital Capacity *Volatile Organic Compounds early respiratory diseases detection exhaled breath analysis infant lung function monitorization of oxidative stress volatile organic compoun;
Notes:		"MedlineSola-Martinez, Rosa A Sanchez-Solis, Manuel Lozano-Terol, Gema Gallego-Jara, Julia Garcia-Marcos, Luis Canovas Diaz, Manuel de Diego Puente, Teresa eng Research Support, Non-U.S. Gov't 2022/01/30 Pediatr Pulmonol. 2022 May; 57(5):1282-1292. doi: 10.1002/ppul.25849. Epub 2022 Feb 7"