| Title: | Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases |
| Author(s): | Schneider MR; Zouboulis CC; |
| Address: | "German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), Berlin, Germany. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany" |
| ISSN/ISBN: | 1600-0625 (Electronic) 0906-6705 (Linking) |
| Abstract: | "Sebocytes, the major cell type in sebaceous glands, are differentiated epithelial cells that gradually accumulate lipids and eventually disrupt, releasing their content (sebum) in a secretory process known as holocrine secretion. Via the hair canal, sebum reaches the skin surface, where it has several known or postulated functions, including pheromonal, thermoregulatory, antimicrobial and antioxidant activities. Altered sebum secretion and/or structural sebaceous gland changes have also been involved in the pathogenesis of skin diseases, such as acne vulgaris and some forms of alopecia. Here, we assess how recent work employing primary sebocytes and sebaceous gland cell lines contributed for our understanding of sebaceous lipogenesis and its role in skin health and disease" |
| Keywords: | *Cell Line Cell Separation Humans Lipogenesis Sebaceous Gland Diseases Sebaceous Glands/*cytology lipid droplets lipids perilipins sebaceous glands; |
| Notes: | "MedlineSchneider, Marlon R Zouboulis, Christos C eng Review Denmark 2018/02/17 Exp Dermatol. 2018 May; 27(5):484-488. doi: 10.1111/exd.13513. Epub 2018 Apr 15" |
