| Title: | "Ribonucleases, antisense RNAs and the control of bacterial plasmids" |
| Author(s): | Saramago M; Barria C; Arraiano CM; Domingues S; |
| Address: | "Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal. Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal. Electronic address: cecilia@itqb.unl.pt. Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal. Electronic address: susanadomingues@itqb.unl.pt" |
| DOI: | 10.1016/j.plasmid.2014.09.003 |
| ISSN/ISBN: | 1095-9890 (Electronic) 0147-619X (Linking) |
| Abstract: | "In the last decade regulatory RNAs have emerged as powerful tools to regulate the expression of genes both in prokaryotes and in eukaryotes. RNases, by degrading these RNA molecules, control the right amount of regulatory RNAs, which is fundamental for an accurate regulation of gene expression in the cell. Remarkably the first antisense RNAs identified were plasmid-encoded and their detailed study was crucial for the understanding of prokaryotic antisense RNAs. In this review we highlight the role of RNases in the precise modulation of antisense RNAs that control plasmid replication, maintenance and transfer" |
| Keywords: | "Bacterial Proteins/genetics/metabolism Bacterial Toxins/genetics Conjugation, Genetic DNA Replication Escherichia coli Proteins/genetics F Factor/genetics *Gene Expression Regulation, Bacterial Pheromones/metabolism Plasmids/*genetics *RNA, Antisense/gene;" |
| Notes: | "MedlineSaramago, Margarida Barria, Catia Arraiano, Cecilia M Domingues, Susana eng Research Support, Non-U.S. Gov't Review 2014/09/30 Plasmid. 2015 Mar; 78:26-36. doi: 10.1016/j.plasmid.2014.09.003. Epub 2014 Sep 28" |
