| Title: | Phenolic Compounds of Rumex roseus L. Extracts and Their Effect as Antioxidant and Cytotoxic Activities |
| Author(s): | Saoudi MM; Bouajila J; Alouani K; |
| Address: | "Laboratoire de Chimie Analytique et Electrochimie, Faculte des Sciences de Tunis, Universite de Tunis El Manar, Campus Universitaire 2092 Tunis, Tunisia. Laboratoire de Genie Chimique, Universite Paul Sabatier, CNRS, INPT, UPS, Toulouse, France" |
| ISSN/ISBN: | 2314-6141 (Electronic) 2314-6133 (Print) |
| Abstract: | "Rumex roseus L. (R. roseus) is acknowledged as an aromatic plant. For its excellent biological properties, it was used as a traditional medicine. The aim of the present study is to evaluate the chemical components and their effect as the biological activities of Tunisian extracts of R. roseus. Consecutive extractions by cold maceration of the aerial part with solvents of increasing polarity (cyclohexane (CYH), dichloromethane (DCM), and methanol (MeOH)) were performed, and the different chemical groups (phenolics, flavonoids, tannins, anthocyanins, etc.) were identified. In addition, the volatile compounds of the obtained extracts were identified before and after derivatization. Moreover, their antioxidant and anticancer activities were evaluated. The analysis of HPLC-DAD revealed the identification of 18 components from organic extracts, among them are, for example, chlorogenic acid and shikonin, while GC-MS analysis allowed the detection of 34 volatile compounds. Some of those compounds were identified for the first time in plant extracts such as pyrazolo[3,4-d] pyrimidine-3,4(2H,5H)-dione (1); L-proline (16); 2-amino-3-hydroxybutanoic acid (19); L-(-)-arabitol (23); D-(-)-fructopyranose (25); and D-(+)-talopyranose (27). DPPH tests revealed that the most important antioxidant activity was found in the methanolic extract with 75.2% inhibition at 50 mg/L and that the highest cytotoxic activity against HCT-116 and MCF-7 was recorded in the dichloromethane extract with 62.1 and 80.0% inhibition at 50 mg/L, respectively. The biological activities were fully correlated with the chemical composition of the different extracts. So, we can suggest that R. roseus is a source of bioactive molecules that could be considered potential alternatives for use in dietary supplements for the prevention or treatment of diseases" |
| Keywords: | "Antioxidants/chemistry/*pharmacology Cell Death/drug effects Chromatography, High Pressure Liquid Gas Chromatography-Mass Spectrometry Phenols/*analysis/chemistry Plant Extracts/*chemistry Rumex/*chemistry Volatile Organic Compounds/analysis;" |
| Notes: | "MedlineSaoudi, Mohamed Marouane Bouajila, Jalloul Alouani, Khaled eng 2021/10/06 Biomed Res Int. 2021 Sep 24; 2021:2029507. doi: 10.1155/2021/2029507. eCollection 2021" |
