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Annu Rev Anal Chem (Palo Alto Calif)

Title:		Real-time clinical monitoring of biomolecules
Author(s):		Rogers ML; Boutelle MG;
Address:		"Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom. m.rogers07@imperial.ac.uk"
Journal Title:		Annu Rev Anal Chem (Palo Alto Calif)
Year:		2013
Volume:		6
Issue:
Page Number:		427 - 453
DOI:		10.1146/annurev.anchem.111808.073648
ISSN/ISBN:		1936-1335 (Electronic) 1936-1327 (Linking)
Abstract:		"Continuous monitoring of clinical biomarkers offers the exciting possibility of new therapies that use biomarker levels to guide treatment in real time. This review explores recent progress toward this goal. We initially consider measurements in body fluids by a range of analytical methods. We then discuss direct tissue measurements performed by implanted sensors; sampling techniques, including microdialysis and ultrafiltration; and noninvasive methods. A future directions section considers analytical methods at the cusp of clinical use"
Keywords:		"Biomarkers Biosensing Techniques/*methods Body Fluids/*chemistry Breath Tests/methods Electrodes, Implanted/adverse effects Feces/chemistry Humans Microdialysis/methods Point-of-Care Systems/statistics & numerical data Skin/chemistry Surgical Flaps Volati;"
Notes:		"MedlineRogers, Michelle L Boutelle, Martyn G eng 094912/Wellcome Trust/United Kingdom DH_/Department of Health/United Kingdom BB_/Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't Review 2013/06/19 Annu Rev Anal Chem (Palo Alto Calif). 2013; 6:427-53. doi: 10.1146/annurev.anchem.111808.073648"