| Title: | Self-administration of a Salmonella vaccine by domestic pigs |
| Author(s): | Robbins RC; Archer C; Gimenez-Lirola LG; Mora-Diaz JC; McGlone JJ; |
| Address: | "R.C. Robbins Swine Consulting Services PLLC, 1113 Alta Vista St., Amarillo, TX, 79106, USA. Laboratory of Animal Behavior, Physiology and Welfare, Texas Tech University, Lubbock, TX, 79409-2141, USA. Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, 50011, USA. Laboratory of Animal Behavior, Physiology and Welfare, Texas Tech University, Lubbock, TX, 79409-2141, USA. john.mcglone@ttu.edu" |
| DOI: | 10.1038/s41598-023-29987-x |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Hand vaccinating is time consuming and inefficient. Oral vaccines delivered by drenching are less likely to be used due to a lack of labor on farms. Current environmental enrichment (EE) technologies do not allow pigs to express certain natural behaviors such as rooting and getting a reward. We developed a sprayer so that domestic pigs can self-apply any liquid. By adding an attractant (pig maternal pheromone), the use of EE devices by individual pigs can be increased. In this study, we used a Salmonella oral vaccine to evaluate efficacy of three delivery methods: (1) Control, no vaccine, (2) hand drenching as labeled, and (3) self-administration by this EE rooting device. All pigs sprayed themselves within 80 min of exposure to the EE device. While control pigs had little or no Salmonella serum and oral fluid IgG or IgA, hand-drenched and self-vaccinated pigs built similar levels of both serum and oral fluid IgA and IgG. We conclude we were able to significantly reduce human labor needed and achieved 100% efficacy in eliciting a serologic response when pigs self-administered a Salmonella vaccine. This technology could benefit commercial pig production while providing an enriched behavioral environment. Self-vaccination could also assist in control or immunization of feral swine and improve domestic pig health and food safety" |
| Keywords: | Humans Swine Animals *Sus scrofa Self Administration *Salmonella Vaccines Immunoglobulin A Immunoglobulin G; |
| Notes: | "MedlineRobbins, Rebecca C Archer, Courtney Gimenez-Lirola, Luis G Mora-Diaz, Juan Carlos McGlone, John J eng Research Support, Non-U.S. Gov't England 2023/02/23 Sci Rep. 2023 Feb 20; 13(1):2972. doi: 10.1038/s41598-023-29987-x" |
