| Title: | Simultaneous delivery of Paclitaxel and Bcl-2 siRNA via pH-Sensitive liposomal nanocarrier for the synergistic treatment of melanoma |
| Author(s): | Reddy TL; Garikapati KR; Reddy SG; Reddy BV; Yadav JS; Bhadra U; Bhadra MP; |
| Address: | "Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad-500007, India. Academy of Scientific and Innovative Research (AcSIR), Training and Development Complex, CSIR Campus, CSIR Road, Taramani, Chennai-600 113, India. Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad-500007, India. Functional Genomics and Gene Silencing Group, CSIR-Centre for Cellular and Molecular Biology (CCMB), Uppal Road, Hyderabad-500007, India" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "pH-sensitive drug carriers that are sensitive to the acidic (pH = ~6.5) microenvironments of tumor tissues have been primarily used as effective drug/gene/siRNA/microRNA carriers for releasing their payloads to tumor cells/tissues. Resistance to various drugs has become a big hurdle in systemic chemotherapy in cancer. Therefore delivery of chemotherapeutic agents and siRNA's targeting anti apoptotic genes possess advantages to overcome the efflux pump mediated and anti apoptosis-related drug resistance. Here, we report the development of nanocarrier system prepared from kojic acid backbone-based cationic amphiphile containing endosomal pH-sensitive imidazole ring. This pH-sensitive liposomal nanocarrier effectively delivers anti-cancer drug (Paclitaxel; PTX) and siRNA (Bcl-2), and significantly inhibits cell proliferation and reduces tumor growth. Tumor inhibition response attributes to the synergistic effect of PTX potency and MDR reversing ability of Bcl-2 siRNA in the tumor supporting that kojic acid based liposomal pH-sensitive nanocarrier as efficient vehicle for systemic co-delivery of drugs and siRNA" |
| Keywords: | "Animals Antineoplastic Agents, Phytogenic/chemistry/*pharmacology Apoptosis/drug effects Cell Line, Tumor Drug Compounding *Drug Delivery Systems Gene Expression Regulation, Neoplastic/drug effects Hydrogen-Ion Concentration Imidazoles/chemistry Liposomes;" |
| Notes: | "MedlineReddy, Teegala Lakshminarayan Garikapati, Koteswara Rao Reddy, S Gopal Reddy, B V Subba Yadav, J S Bhadra, Utpal Bhadra, Manika Pal eng Research Support, Non-U.S. Gov't England 2016/10/28 Sci Rep. 2016 Oct 27; 6:35223. doi: 10.1038/srep35223" |
