| Title: | Taking your breath away: metabolomics breathes life in to personalized medicine |
| Author(s): | Rattray NJ; Hamrang Z; Trivedi DK; Goodacre R; Fowler SJ; |
| Address: | "School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. Electronic address: Nicholas.Rattray@manchester.ac.uk. Manchester Pharmacy School, University of Manchester, Manchester, UK. School of Chemistry and Manchester Institute of Biotechnology, University of Manchester, Manchester, UK. University of Manchester, Manchester Academic Health Science Centre, NIHR Respiratory and Allergy Clinical Research Facility, University Hospital of South Manchester, Manchester, UK; Respiratory Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK. Electronic address: Stephen.Fowler@manchester.ac.uk" |
| DOI: | 10.1016/j.tibtech.2014.08.003 |
| ISSN/ISBN: | 1879-3096 (Electronic) 0167-7799 (Linking) |
| Abstract: | "Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of personalized medicines demanding rapid bespoke diagnosis and treatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advancement. Here, we discuss recent improvements and directions in the development of breath VOC analysis and diagnosis platforms that offer the potential for disease biomarker discovery and disease prognosis" |
| Keywords: | *Breath Tests Humans *Metabolomics *Precision Medicine Volatile Organic Compounds/analysis breathomics eNose mass spectrometry personalized medicine point-of-care volatile organic compounds; |
| Notes: | "MedlineRattray, Nicholas J W Hamrang, Zahra Trivedi, Drupad K Goodacre, Royston Fowler, Stephen J eng BB/C519038/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom MC_QA137293/MRC_/Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't Review England 2014/09/03 Trends Biotechnol. 2014 Oct; 32(10):538-48. doi: 10.1016/j.tibtech.2014.08.003. Epub 2014 Aug 29" |
