| Title: | An Optimistic Vision of Future: Diagnosis of Bacterial Infections by Sensing Their Associated Volatile Organic Compounds |
| Author(s): | Ratiu IA; Bocos-Bintintan V; Monedeiro F; Milanowski M; Ligor T; Buszewski B; |
| Address: | "Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Torun, Poland. Interdisciplinary Centre of Modern Technologies, Nicolaus Copernicus University, Torun, Poland. Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Romania. Faculty of Environmental Science and Engineering, Babes-Bolyai University, Cluj-Napoca, Romania. Department of Chemistry, Faculty of Philosophy, Science and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, CEP, Brazil" |
| DOI: | 10.1080/10408347.2019.1663147 |
| ISSN/ISBN: | 1547-6510 (Electronic) 1040-8347 (Linking) |
| Abstract: | "Simple tests using sniff analysis that have the ability of diagnosing and rapidly distinguishing between infections due to different bacteria are urgently required by medical community worldwide. Professionals interested in this topic wish for these tests to be simultaneously cheap, fast, easily applicable, non-invasive, robust, reliable, and sensitive. Current analytical instrumentation has already the ability for performing real time (minutes or a few dozens of minutes) analysis of volatile bacterial biomarkers (the VOCs emitted by bacteria). Although many articles are available, a review displaying an objective evaluation of the current status in the field is still needed. This review tries to present an overview regarding the bacterial biomarkers released from in vitro cultivation of various bacterial strains and also from different biological matrices investigated, over the last 10 years. We have described results of relevant studies, which used modern analytical techniques to evaluate specific biomarker profiles associated with bacterial infections. Our purpose was to present a comprehensive view of available possibilities for detection of emitted bacterial VOCs from different matrices. We intend that this review to be of general interest for both medical doctors and for all researchers preoccupied with bacterial infectious diseases and their rapid diagnosis using analytical instrumentation" |
| Keywords: | Animals Bacteria/metabolism Bacterial Infections/*diagnosis/urine Biomarkers/metabolism/urine Feces/chemistry/microbiology Humans Volatile Organic Compounds/*metabolism/urine Analytical instrumentation bacterial biomarkers bacterial infection diagnostic t; |
| Notes: | "MedlineRatiu, Ileana-Andreea Bocos-Bintintan, Victor Monedeiro, Fernanda Milanowski, Maciej Ligor, Tomasz Buszewski, Boguslaw eng Review 2019/09/14 Crit Rev Anal Chem. 2020; 50(6):501-512. doi: 10.1080/10408347.2019.1663147. Epub 2019 Sep 12" |
