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Environ Pollut

Title:		"Urinary metabolites of multiple volatile organic compounds among general population in Wuhan, central China: Inter-day reproducibility, seasonal difference, and their associations with oxidative stress biomarkers"
Author(s):		Qian X; Wan Y; Wang A; Xia W; Yang Z; He Z; Xu S;
Address:		"Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: d201981370@hust.edu.cn. Institute of Environmental Health, Wuhan Centers for Disease Control & Prevention, Wuhan, Hubei, 430024, PR China. Electronic address: Yanjian.Wan@whcdc.org. Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: D202081540@hust.edu.cn. Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: xiawei@hust.edu.cn. SCIEX, Shanghai, 200335, PR China. Electronic address: 123yangzong@sina.com. Institute of Environmental Health, Wuhan Centers for Disease Control & Prevention, Wuhan, Hubei, 430024, PR China. Electronic address: hygiene@whcdc.org. Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: xust@hust.edu.cn"
Journal Title:		Environ Pollut
Year:		2021
Volume:		20210805
Issue:
Page Number:		117913 -
DOI:		10.1016/j.envpol.2021.117913
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"General population are concurrently and extensively exposed to many volatile organic compounds (VOCs), including some Group 1 human carcinogens, such as 1,3-butadiene. However, only a few studies assessed internal exposure levels of VOCs; particularly, very limited studies have examined associations between the urinary concentrations of multiple VOC metabolites (mVOCs) and oxidative stress biomarkers (OSBs) among the general population. In this study, 21 mVOCs and three OSBs including 8-hydroxy-2'-deoxyguanosine (8-OHdG; for DNA), 8-hydroxyguanosine (8-OHG; for RNA), and 4-hydroxy nonenal mercapturic acid (HNEMA; for lipid) were measured in 406 urine samples collected from 128 healthy adults during autumn and winter of 2018 in Wuhan, central China, including repeated samples taken in 3 d from 75 volunteers. Inter-day reproducibility for most mVOCs was good to excellent; urinary concentrations of mVOCs in winter were generally higher than those in autumn. Risk assessment was conducted by calculating hazard quotients for the parent compounds, and the results suggested that acrolein, 1,3-butadiene, and cyanide should be considered as high-priority hazardous ones for management. After false-discovery adjustment, 16 of the studied mVOCs were positively associated with 8-OHdG and 8-OHG (beta values ranged from 0.04 to 0.48), and four mVOCs were positively associated with HNEMA (beta values ranged from 0.21 to 0.78). Weighted quantile sum regression analyses were used to assess associations of mVOC mixture and OSBs, and we found significantly positive associations between the mixture index and OSBs, among which the strongest mVOC contributors for the associations were 2-methylhippuric acid for both DNA (20%) and RNA (17%) oxidative damage, and trans,trans-muconic acid (50%) for lipid peroxidation. This study firstly reported good to excellent short-term reproducibility, seasonal difference in autumn and winter, and possible health risk in urinary concentrations of multiple mVOCs among the general population"
Keywords:		Adult Biomarkers China Humans Oxidative Stress Reproducibility of Results Seasons *Volatile Organic Compounds General population Oxidative stress biomarkers Urine Variability Volatile organic compound metabolites Weighted quantile sum regression;
Notes:		"MedlineQian, Xi Wan, Yanjian Wang, Aizhen Xia, Wei Yang, Zong He, Zhenyu Xu, Shunqing eng England 2021/08/25 Environ Pollut. 2021 Nov 15; 289:117913. doi: 10.1016/j.envpol.2021.117913. Epub 2021 Aug 5"