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FEMS Microbiol Lett

Title:		Peptide pheromone induced cell death of Streptococcus mutans
Author(s):		Qi F; Kreth J; Levesque CM; Kay O; Mair RW; Shi W; Cvitkovitch DG; Goodman SD;
Address:		"Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, United States"
Journal Title:		FEMS Microbiol Lett
Year:		2005
Volume:		251
Issue:		2
Page Number:		321 - 326
DOI:		10.1016/j.femsle.2005.08.018
ISSN/ISBN:		0378-1097 (Print) 0378-1097 (Linking)
Abstract:		"Streptococcus mutans is considered one of the main causative agents of human dental caries. Cell-cell communication through two-component signal transduction systems (TCSTS) plays an important role in the pathogenesis of S. mutans. One of the S. mutans TCSTS, ComDE, controls both competence development and biofilm formation. In this study, we showed that addition of exogenous competence-stimulating peptide (CSP) beyond the levels necessary for competence inhibited the growth of S. mutans in a ComDE-dependent manner. We also demonstrated that further increases of CSP stopped S. mutans cell division leading to cell death. Use of CSP as a possible therapeutic agent is discussed"
Keywords:		"Bacterial Proteins/metabolism Biofilms Cell Death Peptides Pheromones/*pharmacology Streptococcus mutans/*drug effects/metabolism/physiology Transformation, Bacterial;"
Notes:		"MedlineQi, Fengxia Kreth, J Levesque, Celine M Kay, Olga Mair, Richard W Shi, Wenyuan Cvitkovitch, Dennis G Goodman, Steven D eng R01 DE013230/DE/NIDCR NIH HHS/ U01-DE15018/DE/NIDCR NIH HHS/ R01 DE013965/DE/NIDCR NIH HHS/ R01 DE013230-0/DE/NIDCR NIH HHS/ T32 DE007296/DE/NIDCR NIH HHS/ R01-DE014757/DE/NIDCR NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. England 2005/09/17 FEMS Microbiol Lett. 2005 Oct 15; 251(2):321-6. doi: 10.1016/j.femsle.2005.08.018"