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ACS Chem Neurosci

Title:		Transient receptor potential channels as targets for phytochemicals
Author(s):		Premkumar LS;
Address:		"Department of Pharmacology, Southern Illinois University School of Medicine , Springfield, Illinois 62702, United States"
Journal Title:		ACS Chem Neurosci
Year:		2014
Volume:		20140624
Issue:		11
Page Number:		1117 - 1130
DOI:		10.1021/cn500094a
ISSN/ISBN:		1948-7193 (Electronic) 1948-7193 (Print) 1948-7193 (Linking)
Abstract:		"To date, 28 mammalian transient receptor potential (TRP) channels have been cloned and characterized. They are grouped into six subfamilies on the basis of their amino acid sequence homology: TRP Ankyrin (TRPA), TRP Canonical (TRPC), TRP Melastatin (TRPM), TRP Mucolipin (TRPML), TRP Polycystin (TRPP), and TRP Vanilloid (TRPV). Most of the TRP channels are nonselective cation channels expressed on the cell membrane and exhibit variable permeability ratios for Ca(2+) versus Na(+). They mediate sensory functions (such as vision, nociception, taste transduction, temperature sensation, and pheromone signaling) and homeostatic functions (such as divalent cation flux, hormone release, and osmoregulation). Significant progress has been made in our understanding of the specific roles of these TRP channels and their activation mechanisms. In this Review, the emphasis will be on the activation of TRP channels by phytochemicals that are claimed to exert health benefits. Recent findings complement the anecdotal evidence that some of these phytochemicals have specific receptors and the activation of which is responsible for the physiological effects. Now, the targets for these phytochemicals are being unveiled; a specific hypothesis can be proposed and tested experimentally to infer a scientific validity of the claims of the health benefits. The broader and pressing issues that have to be addressed are related to the quantities of the active ingredients in a given preparation, their bioavailability, metabolism, adverse effects, excretion, and systemic versus local effects"
Keywords:		Animals Humans Phytochemicals/chemistry/*pharmacology Transient Receptor Potential Channels/*drug effects/*metabolism TRP channel botanical neuropeptide phytochemical;
Notes:		"MedlinePremkumar, Louis S eng DA028017/DA/NIDA NIH HHS/ Research Support, N.I.H., Extramural Review 2014/06/14 ACS Chem Neurosci. 2014 Nov 19; 5(11):1117-30. doi: 10.1021/cn500094a. Epub 2014 Jun 24"