« Previous AbstractThe volatile chemistry of orchid pollination    Next AbstractTubular plexiglas maze »

Anal Chem

Title:		Standard Validation Protocol for Selected Ion Flow Tube Mass Spectrometry Methods Applied to Direct Headspace Analysis of Aqueous Volatile Organic Compounds
Author(s):		Perkins MJ; Langford VS;
Address:		"Anatune Limited, Wellbrook Court, Girton Road, Cambridge CB3 0NA, United Kingdom. Syft Technologies Limited, 3 Craft Place, Christchurch 8024, New Zealand"
Journal Title:		Anal Chem
Year:		2021
Volume:		20210608
Issue:		24
Page Number:		8386 - 8392
DOI:		10.1021/acs.analchem.1c01310
ISSN/ISBN:		1520-6882 (Electronic) 0003-2700 (Linking)
Abstract:		"Analysis of volatile organic compounds (VOCs) in water is conventionally conducted using gas chromatography (GC)-based methods, for which sample preparation demands are relatively high and throughput is relatively low due to the time taken to achieve chromatographic separation. Direct mass spectrometry (DMS) techniques such as selected ion flow tube mass spectrometry (SIFT-MS) have potential to analyze water headspace (HS) at high sensitivity with minimal sample preparation, eliminating preconcentration/purging and/or water management steps. However, the dearth of guidance for validation of DMS methods is an impediment to their adoption in routine analysis. This study applies and adapts an internationally recognized pharmaceutical industry guidance document for method validation to a prototypical SIFT-MS headspace analysis method for 17 toxic VOCs in water. The approach to validation is, however, applicable to any routine analysis conducted using SIFT-MS, and very likely to any methods developed using other DMS techniques. For the method developed and validated here, linearities (as measured by the linear regression coefficient, R(2)) were better than 0.990 for all compounds. Repeatability (measured using relative standard deviation, RSD) was less than 10% for all compounds. Similar method performance was observed for accuracy and recovery. The performance criteria achieved by this HS-SIFT-MS method suggest it has potential application in environmental and pharmaceutical routine analyses, perhaps as a rapid screening tool"
Keywords:		Gas Chromatography-Mass Spectrometry Mass Spectrometry *Volatile Organic Compounds/analysis Water;
Notes:		"MedlinePerkins, Mark J Langford, Vaughan S eng 2021/06/09 Anal Chem. 2021 Jun 22; 93(24):8386-8392. doi: 10.1021/acs.analchem.1c01310. Epub 2021 Jun 8"