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Exp Parasitol

Title:		(R)-Carvone is a potential soil fumigant against Meloidogyne incognita whose likely enzymatic target in the nematode is acetylcholinesterase
Author(s):		Pacule HB; Vanegas JAG; Terra WC; Campos VP; Oliveira DF;
Address:		"Universidade Federal de Lavras, Departamento de Quimica, Lavras-MG, P.O.box, 37200-900, Brazil. Universidade Federal de Quimica, Departamento de Fitopatologia, Lavras-MG, P.O.box, 37200-900, Brazil. Universidade Federal de Lavras, Departamento de Quimica, Lavras-MG, P.O.box, 37200-900, Brazil. Electronic address: denilson@ufla.br"
Journal Title:		Exp Parasitol
Year:		2022
Volume:		20220820
Issue:
Page Number:		108359 -
DOI:		10.1016/j.exppara.2022.108359
ISSN/ISBN:		1090-2449 (Electronic) 0014-4894 (Linking)
Abstract:		"To contribute to the development of new fumigant nematicides for the control of the plant-parasitic nematode Meloidogyne incognita, this study started with 31 volatile organic compounds reported as toxic to nematodes. At 500 mug/mL, alpha-ionone, (S)-carvone, (R)-carvone, 2-methylpropyl acetate, undecan-2-one, decan-2-one, and dodecan-2-one caused mortalities to M. incognita second-stage juveniles (J2) that were similar to those obtained with the commercial nematicides carbofuran (170 mug/mL) and fluensulfone (42.2 mug/mL). (R)-carvone, with a lethal concentration to 50% J2 (LC(50)) equal to 524 mug/mL, was selected for subsequent studies. When J2 were exposed to the (R)-carvone solution, the infectivity and reproduction on tomato were reduced. In the M. incognita egg hatching assay, (R)-carvone behaved like a true ovicide. When employed as a fumigant, (R)-carvone (3.9 g/L) was as efficient as the soil fumigant dazomet (0.245 g/L) in eliminating eggs of the nematode in a substrate to be used for tomato planting. According to in silico studies employing pharmacophoric searches and molecular docking, acetylcholinesterases are the target of (R)-carvone in the nematode"
Keywords:		Acetylcholinesterase Animals Antinematodal Agents/chemistry/pharmacology Cyclohexane Monoterpenes *Solanum lycopersicum/parasitology Molecular Docking Simulation Soil *Tylenchoidea Computational chemistry Molecular docking Root-knot nematode Tomato Volati;
Notes:		"MedlinePacule, Horacio B Vanegas, Javier A G Terra, Willian C Campos, Vicente P Oliveira, Denilson F eng 2022/08/24 Exp Parasitol. 2022 Oct; 241:108359. doi: 10.1016/j.exppara.2022.108359. Epub 2022 Aug 20"