| Title: | Synthesis of new 3- and 4-substituted analogues of acyl homoserine lactone quorum sensing autoinducers |
| Author(s): | Olsen JA; Severinsen R; Rasmussen TB; Hentzer M; Givskov M; Nielsen J; |
| Address: | "Department of Chemistry, Bld. 207, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark" |
| DOI: | 10.1016/s0960-894x(01)00756-9 |
| ISSN/ISBN: | 0960-894X (Print) 0960-894X (Linking) |
| Abstract: | "The quorum sensing mechanism in Gram-negative bacteria uses small intercellular signal molecules, N-acyl-homoserine lactones (AHLs), to control transcription of specific genes in relation to population density. In this communication, we describe the parallel synthesis of new AHL analogues, in which substituents have been introduced into the 3- and 4-positions of the lactone ring. These analogues have been screened for their ability to activate and inhibit a Vibrio fischeri LuxI/LuxR-derived quorum sensing reporter system" |
| Keywords: | "4-Butyrolactone/*analogs & derivatives/*chemistry/pharmacology Bacterial Proteins/*chemistry Gene Expression Regulation, Bacterial/drug effects Gram-Negative Bacteria/*drug effects/genetics Indicators and Reagents Luminescence Pheromones/*chemistry/*pharm;" |
| Notes: | "MedlineOlsen, J A Severinsen, R Rasmussen, T B Hentzer, M Givskov, M Nielsen, J eng Research Support, Non-U.S. Gov't England 2002/01/30 Bioorg Med Chem Lett. 2002 Feb 11; 12(3):325-8. doi: 10.1016/s0960-894x(01)00756-9" |
