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Biochem Cell Biol

Title:		The regulation of membrane fusion during sexual development in Dictyostelium discoideum
Author(s):		O'Day DH; Lydan MA;
Address:		"Department of Zoology, University of Toronto, Mississauga, Ont., Canada"
Journal Title:		Biochem Cell Biol
Year:		1989
Volume:		67
Issue:		7
Page Number:		321 - 326
DOI:		10.1139/o89-050
ISSN/ISBN:		0829-8211 (Print) 0829-8211 (Linking)
Abstract:		"During the first 24 h of sexual development in Dictyostelium discoideum, three sequential events of membrane fusion occur: gamete fusion, pronuclear fusion, and phagocytosis. The early events of sexual development are regulated by a diverse group of endogenous molecules: (i) a volatile sexual pheromone, (ii) a protein cell fusion inducing factor (CFIF), (iii) a low molecular weight autoinhibitor, (iv) and cyclic AMP. CFIC enhances cell fusion while the autoinhibitor and cyclic AMP both inhibit the event. Both extracellular and intracellular calcium ions are essential for cell and pronuclear fusion. Pharmacological analyses show that the intracellular functions of the divalent cation in these processes are mediated by calmodulin. The autoinhibitor appears to function by inhibiting calmodulin activity. Glucose, mannose, and N-acetylglucosamine containing glycoproteins have been shown to function in both cell fusion and phagocytosis. The interplay between all of these diverse molecules is examined and a review of all of the recent literature is presented"
Keywords:		Cell Membrane/physiology Dictyostelium/*growth & development/ultrastructure *Membrane Fusion;
Notes:		"MedlineO'Day, D H Lydan, M A eng Research Support, Non-U.S. Gov't Review Canada 1989/07/01 Biochem Cell Biol. 1989 Jul; 67(7):321-6. doi: 10.1139/o89-050"