| Title: | Risk of dermal and inhalation exposure to chlorantraniliprole assessed by using whole-body dosimetry in Korea |
| Author(s): | Noh HH; Lee JY; Park HK; Lee JW; Jo SH; Kim JH; Kwon H; Kyung KS; |
| Address: | "Department of Agro-food Safety and Crop protection, National Institute of Agricultural Science, Rural Development Administration, Wanju, Republic of Korea. Residue Research Team, Research Institute, NongHyup Chemical, Okcheon, Republic of Korea. Department of Environmental and Biological Chemistry, College of Agriculture, Life and Environment Science, Chungbuk National University, Cheongju, Republic of Korea. Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea" |
| ISSN/ISBN: | 1526-4998 (Electronic) 1526-498X (Linking) |
| Abstract: | "BACKGROUND: We determined the characteristics and evaluated associated risks of sprayed pesticide exposure among workers cultivating Korean cabbage. The test pesticide, a mixture of 3% chlorantraniliprole and 4% indoxacarb wettable granules diluted 2000 times, was sprayed on Korean cabbage within a 3000 m(2) area in Goesan, Korea. Dermal exposures were measured using a whole-body dosimetry method. RESULTS: Exposure to chlorantraniliprole was observed among ten individuals, ranging from 140.4 to 4234.0 microg person(-1) . The legs were the most prominent exposure area (86.35%), with the face being the least exposed (0.06%). Exposure risk was assessed by calculating the margin of safety (MOS) on the exposure amount for each body part. The MOS based on dermal and inhalation exposure doses ranged from 59 to 1765. CONCLUSION: Exposure was the greatest for the legs, probably as a result of the low height of the crop and the use of a long-wand sprayer. An MOS value >1 indicates a low risk for applicators using this method of application. However, with tall crops, exposure level and MOS values can vary widely, as MOS increases or decreases based on exposure dose. Therefore, future research is needed to better understand appropriate safety precautions when working with potent pesticides. (c) 2018 Society of Chemical Industry" |
| Keywords: | Humans Inhalation Exposure/*analysis Insecticides/*metabolism Male Occupational Exposure/*analysis Republic of Korea Risk Assessment *Skin Absorption ortho-Aminobenzoates/*metabolism chlorantraniliprole dermal exposure inhalation exposure margin of safety; |
| Notes: | "MedlineNoh, Hyun H Lee, Jae Y Park, Hyo K Lee, Jung W Jo, Seung H Kim, Jeong-Han Kwon, Hyeyoung Kyung, Kee S eng PJ0099480320180/Research Program for Agriculture Science & Technology Development/ National Academy of Agricultural Sciences, Rural Development Administration, Republic of Korea/ England 2018/10/31 Pest Manag Sci. 2019 Apr; 75(4):1159-1165. doi: 10.1002/ps.5255. Epub 2019 Jan 17" |
