| Title: | "The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Glycine max)" |
| Author(s): | Navratilova M; Raisova Stuchlikova L; Motkova K; Szotakova B; Skalova L; Langhansova L; Podlipna R; |
| Address: | "Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. Laboratory of Plant Biotechnologies, Institute of Experimental Botany, Czech Academy of Sciences, 165 02 Praha 6-Lysolaje, Czech Republic" |
| DOI: | 10.3390/molecules25163655 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "In recent years interest has grown in the occurrence and the effects of pharmaceuticals in the environment. The aim of this work is to evaluate the risk of fertilizing crops with manure from livestock treated with anthelmintics. The present study was designed to follow the fate of the commonly used anthelmintic drug, ivermectin (IVM) and its metabolites in soybeans (Glycine max (L.) Merr.), a plant that is grown and consumed world-wide for its high content of nutritional and health-beneficial substances. In vitro plantlets and soybean plants, cultivated in a greenhouse, were used for this purpose. Our results showed the uptake of IVM and its translocation to the leaves, but not in the pods and the beans. Four IVM metabolites were detected in the roots, and one in the leaves. IVM exposure decreased slightly the number and weight of the beans and induced changes in the activities of antioxidant enzymes. In addition, the presence of IVM affected the proportion of individual isoflavones and reduced the content of isoflavones aglycones, which might decrease the therapeutic value of soybeans. Fertilization of soybean fields with manure from IVM-treated animals appears to be safe for humans, due to the absence of IVM in beans, the food part of plants. On the other hand, it could negatively affect soybean plants and herbivorous invertebrates" |
| Keywords: | Animals;Antioxidants/*metabolism Antiparasitic Agents/pharmacology Biological Transport Isoflavones/*metabolism Ivermectin/*pharmacology Plant Leaves/drug effects/growth & development/*metabolism Plant Roots/drug effects/growth & development/*metabolism Seeds/dru; |
| Notes: | "MedlineNavratilova, Martina Raisova Stuchlikova, Lucie Motkova, Katerina Szotakova, Barbora Skalova, Lenka Langhansova, Lenka Podlipna, Radka eng 18-08452S/Czech Science Foundation/ SVV260550/Grantova Agentura, Univerzita Karlova/ CZ.02.1.01/0.0/0.0/16_019/0000841/Ministerstvo Skolstvi, Mladeze a Telovychovy/ CZ.02.1.01/0.0/0.0/16_019/0000738/Ministerstvo Skolstvi, Mladeze a Telovychovy/ Switzerland 2020/08/17 Molecules. 2020 Aug 11; 25(16):3655. doi: 10.3390/molecules25163655" |
