| Title: | Prospects for malaria control through manipulation of mosquito larval habitats and olfactory-mediated behavioural responses using plant-derived compounds |
| Author(s): | Muema JM; Bargul JL; Njeru SN; Onyango JO; Imbahale SS; |
| Address: | "Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya. jackson_mbithi@yahoo.com. Department of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000-00200, Nairobi, Kenya. Molecular Biology and Bioinformatics Unit, International Centre of Insect Physiology and Ecology, P.O. Box 30772-00100, Nairobi, Kenya. Department of Medicine, Faculty of Health Sciences, Kisii University, P.O. Box 408-40200, Kisii, Kenya. Present Address: Fritz Lipmann Institute (FLI) - Leibniz Institute of Aging Research, D-07745, Jena, Germany. Department of Chemical Science and Technology, Technical University of Kenya, P.O. Box 52428-00200, Nairobi, Kenya. Department of Applied and Technical Biology, Technical University of Kenya, P.O. Box 52428-00200, Nairobi, Kenya" |
| DOI: | 10.1186/s13071-017-2122-8 |
| ISSN/ISBN: | 1756-3305 (Electronic) 1756-3305 (Linking) |
| Abstract: | "Malaria presents an overwhelming public health challenge, particularly in sub-Saharan Africa where vector favourable conditions and poverty prevail, potentiating the disease burden. Behavioural variability of malaria vectors poses a great challenge to existing vector control programmes with insecticide resistance already acquired to nearly all available chemical compounds. Thus, approaches incorporating plant-derived compounds to manipulate semiochemical-mediated behaviours through disruption of mosquito olfactory sensory system have considerably gained interests to interrupt malaria transmission cycle. The combination of push-pull methods and larval control have the potential to reduce malaria vector populations, thus minimising the risk of contracting malaria especially in resource-constrained communities where access to synthetic insecticides is a challenge. In this review, we have compiled information regarding the current status of knowledge on manipulation of larval ecology and chemical-mediated behaviour of adult mosquitoes with plant-derived compounds for controlling mosquito populations. Further, an update on the current advancements in technologies to improve longevity and efficiency of these compounds for field applications has been provided" |
| Keywords: | "Animals Disease Transmission, Infectious/*prevention & control Humans Insect Repellents/*pharmacology Malaria/*prevention & control Mosquito Control/*methods Pheromones/*pharmacology Phytochemicals/*pharmacology Anopheline mosquitoes Integrated vector man;" |
| Notes: | "MedlineMuema, Jackson M Bargul, Joel L Njeru, Sospeter N Onyango, Joab O Imbahale, Susan S eng Review England 2017/04/18 Parasit Vectors. 2017 Apr 17; 10(1):184. doi: 10.1186/s13071-017-2122-8" |
