| Title: | A single nucleotide polymorphism in the CYP2E1 gene promoter affects skatole content in backfat of boars of two commercial Duroc-sired crossbred populations |
| Author(s): | Morlein D; Lungershausen M; Steinke K; Sharifi AR; Knorr C; |
| Address: | "Department of Animal Science, University of Gottingen, Gottingen, Germany" |
| DOI: | 10.1016/j.meatsci.2012.06.031 |
| ISSN/ISBN: | 1873-4138 (Electronic) 0309-1740 (Linking) |
| Abstract: | "The prevention of unpleasant boar taint is the main reason for castration of male piglets. This study aimed to investigate how the malodorous compound skatole is affected by a single nucleotide polymorphism (g.2412 C>T at -586 ATG) in the porcine cytochrome p450 II E1 (CYP2E1) gene. 119 boars of two commercial Duroc-sired crossbred populations raised at different farms were investigated. Skatole and androstenone in backfat averaged 114+/-125 ng/g and 1206+/-895 ng/g melted fat, respectively. The frequency of the genotypes CC, CT, and TT was 25, 52, and 23%, respectively. CC boars had the highest average skatole levels (175 ng/g) compared to CT (92 ng/g) and TT (93 ng/g). Applying suggested sensory threshold levels for skatole (>150 ng/g) and androstenone (>2000 ng/g), 30% of the carcasses may be unacceptably tainted while the proportion of tainted carcasses is significantly higher within genotype CC (56.7%) compared to genotypes CT (24.3%) and TT (14.8%). Effective reduction of tainted carcasses appears feasible applying marker assisted selection" |
| Keywords: | "Adipose Tissue, White/chemistry Androstenes/adverse effects/analysis Animals Back Crosses, Genetic Cytochrome P-450 CYP2E1/*genetics/metabolism Dietary Fats/*analysis *Food Contamination/prevention & control Gene Frequency Genetic Association Studies/vete;" |
| Notes: | "MedlineMorlein, Daniel Lungershausen, Mara Steinke, Kirsten Sharifi, Ahmad Reza Knorr, Christoph eng Research Support, Non-U.S. Gov't England 2012/07/17 Meat Sci. 2012 Dec; 92(4):739-44. doi: 10.1016/j.meatsci.2012.06.031. Epub 2012 Jun 28" |
