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Crit Rev Microbiol

Title:		Peptide conversations in Gram-positive bacteria
Author(s):		Monnet V; Juillard V; Gardan R;
Address:		"a INRA, MICALIS, Domaine de Vilvert , Jouy-en-Josas , France"
Journal Title:		Crit Rev Microbiol
Year:		2016
Volume:		20140908
Issue:		3
Page Number:		339 - 351
DOI:		10.3109/1040841X.2014.948804
ISSN/ISBN:		1549-7828 (Electronic) 1040-841X (Linking)
Abstract:		"Within Gram-positive bacteria, the expression of target genes is controlled at the population level via signaling peptides, also known as pheromones. Pheromones control a wide range of functions, including competence, virulence, and others that remain unknown. Until now, their role in bacterial gene regulation has probably been underestimated; indeed, bacteria are able to produce, by ribosomal synthesis or surface protein degradation, an extraordinary variety of peptides which are released outside bacteria and among which, some are pheromones that mediate cell-to-cell communication. The review aims at giving an updated overview of these peptide-dependant communication pathways. More specifically, it follows the whole peptide circuit from the peptide production and secretion in the extracellular medium to its interaction with sensors at bacterial surface or re-import into the bacteria where it plays its regulation role. In recent years, as we have accumulated more knowledge about these systems, it has become apparent that they are more complex than they first appeared. For this reason, more research on peptide-dependant pathways is needed to develop new strategies for controlling functions of interest in Gram-positive bacteria. In particular, such research could lead to alternatives to the use of antibiotics against pathogenic bacteria. In perspective, the review identifies new research questions that emerge in this field and that have to be addressed"
Keywords:		"Bacterial Proteins/genetics/metabolism Gene Expression Regulation, Bacterial Gram-Positive Bacteria/genetics/*metabolism Peptides/*metabolism Cell-cell communication gram-positive bacteria pheromone quorum sensing signaling peptide;"
Notes:		"MedlineMonnet, Veronique Juillard, Vincent Gardan, Rozenn eng Review England 2014/09/10 Crit Rev Microbiol. 2016 May; 42(3):339-51. doi: 10.3109/1040841X.2014.948804. Epub 2014 Sep 8"