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Sci Rep

Title:		A sex-inducing pheromone triggers cell cycle arrest and mate attraction in the diatom Seminavis robusta
Author(s):		Moeys S; Frenkel J; Lembke C; Gillard JT; Devos V; Van den Berge K; Bouillon B; Huysman MJ; De Decker S; Scharf J; Bones A; Brembu T; Winge P; Sabbe K; Vuylsteke M; Clement L; De Veylder L; Pohnert G; Vyverman W;
Address:		"Protistology and Aquatic Ecology, Department of Biology, Ghent University, 9000 Ghent, Belgium. Department of Plant Systems Biology, VIB, B-9052 Ghent, Belgium. Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium. Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University, 07743 Jena, Germany. Department of Biology, California State University, 9001 Stockdale Highway, Bakersfield, CA 93311, USA. Department of Applied Mathematics, Computer Science and Statistics, Ghent University, 9000 Ghent, Belgium. Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway"
Journal Title:		Sci Rep
Year:		2016
Volume:		20160120
Issue:
Page Number:		19252 -
DOI:		10.1038/srep19252
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Although sexual reproduction is believed to play a major role in the high diversification rates and species richness of diatoms, a mechanistic understanding of diatom life cycle control is virtually lacking. Diatom sexual signalling is controlled by a complex, yet largely unknown, pheromone system. Here, a sex-inducing pheromone (SIP(+)) of the benthic pennate diatom Seminavis robusta was identified by comparative metabolomics, subsequently purified, and physicochemically characterized. Transcriptome analysis revealed that SIP(+) triggers the switch from mitosis-to-meiosis in the opposing mating type, coupled with the transcriptional induction of proline biosynthesis genes, and the release of the proline-derived attraction pheromone. The induction of cell cycle arrest by a pheromone, chemically distinct from the one used to attract the opposite mating type, highlights the existence of a sophisticated mechanism to increase chances of mate finding, while keeping the metabolic losses associated with the release of an attraction pheromone to a minimum"
Keywords:		Animals *Cell Cycle Checkpoints/drug effects Diatoms/*physiology Gene Expression Regulation/drug effects Glutamic Acid/metabolism Guanylate Cyclase/genetics/metabolism Meiosis Metabolic Networks and Pathways Metabolome Metabolomics/methods Mitosis Phospho;
Notes:		"MedlineMoeys, Sara Frenkel, Johannes Lembke, Christine Gillard, Jeroen T F Devos, Valerie Van den Berge, Koen Bouillon, Barbara Huysman, Marie J J De Decker, Sam Scharf, Julia Bones, Atle Brembu, Tore Winge, Per Sabbe, Koen Vuylsteke, Marnik Clement, Lieven De Veylder, Lieven Pohnert, Georg Vyverman, Wim eng Research Support, Non-U.S. Gov't England 2016/01/21 Sci Rep. 2016 Jan 20; 6:19252. doi: 10.1038/srep19252"