| Title: | Pro-inflammatory effects and oxidative stress in lung macrophages and epithelial cells induced by ambient particulate matter |
| Author(s): | Michael S; Montag M; Dott W; |
| Address: | "Institute of Hygiene and Environmental Medicine, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany; Human Technology Centre, RWTH Aachen University, Theaterplatz 14, 52056 Aachen, Germany. Electronic address: sabrina.michael@rwth-aachen.de" |
| DOI: | 10.1016/j.envpol.2013.01.026 |
| ISSN/ISBN: | 1873-6424 (Electronic) 0269-7491 (Linking) |
| Abstract: | "The objective of this study was to compare the toxicological effects of different source-related ambient PM10 samples in regard to their chemical composition. In this context we investigated airborne PM from different sites in Aachen, Germany. For the toxicological investigation human alveolar epithelial cells (A549) and murine macrophages (RAW264.7) were exposed from 0 to 96 h to increasing PM concentrations (0-100 mug/ml) followed by analyses of cell viability, pro-inflammatory and oxidative stress responses. The chemical analysis of these particles indicated the presence of 21 elements, water-soluble ions and PAHs. The toxicological investigations of the PM10 samples demonstrated a concentration- and time-dependent decrease in cell viability and an increase in pro-inflammatory and oxidative stress markers" |
| Keywords: | "Air Pollutants/analysis/*toxicity Animals Germany Humans Macrophages, Alveolar/drug effects Mice Oxidative Stress Particulate Matter/analysis/*toxicity Polycyclic Aromatic Hydrocarbons/toxicity Pulmonary Alveoli/drug effects A549 Al Aluminum Arsenic As Ca;" |
| Notes: | "MedlineMichael, S Montag, M Dott, W eng Research Support, Non-U.S. Gov't England 2013/03/07 Environ Pollut. 2013 Dec; 183:19-29. doi: 10.1016/j.envpol.2013.01.026. Epub 2013 Feb 23" |
