| Title: | Pediatric tuberculosis detection using trained African giant pouched rats |
| Author(s): | Mgode GF; Cox CL; Mwimanzi S; Mulder C; |
| Address: | "Sokoine University of Agriculture, Pest Management Centre, African Centre of Excellence for Innovative Rodent Pest Management and Biosensor Technology Development, Morogoro, Tanzania. gmgode@sua.ac.tz. Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling - APOPO, Tuberculosis Department, Sokoine University of Agriculture, Morogoro, Tanzania" |
| ISSN/ISBN: | 1530-0447 (Electronic) 0031-3998 (Linking) |
| Abstract: | "BACKGROUND: Tuberculosis (TB) diagnosis in children is a challenge with up to 94% of children with TB treated empirically in TB high-burden countries. Therefore, new diagnostic tests are needed for TB diagnosis. We determined the performance of trained rats in the diagnosis of pediatric TB and whether they can improve detection rate compared to the standard of care. METHODS: Presumptive TB patients in 24 TB clinics in Tanzania were tested. Samples indicated as TB-positive by rats underwent confirmation by concentrated smear microscopy. TB yield of bacteriologically confirmed pediatric TB patients ( |
| Keywords: | "Adolescent Animals Child Child, Preschool Clinical Laboratory Techniques/*methods Diagnostic Tests, Routine/*standards Female Humans Infant Male Mass Screening/methods Microscopy Mycobacterium tuberculosis Odorants Pediatrics/methods Reproducibility of Re;" |
| Notes: | "MedlineMgode, Georgies F Cox, Christophe L Mwimanzi, Stephen Mulder, Christiaan eng Research Support, Non-U.S. Gov't 2018/04/05 Pediatr Res. 2018 Jul; 84(1):99-103. doi: 10.1038/pr.2018.40. Epub 2018 Apr 4" |
