| Title: | Signal transduction and growth control in yeast |
| Author(s): | Schultz J; Ferguson B; Sprague GF; |
| Address: | "Institute of Molecular Biology, University of Oregon, Eugene 97403-1229, USA" |
| DOI: | 10.1016/s0959-437x(95)90050-0 |
| ISSN/ISBN: | 0959-437X (Print) 0959-437X (Linking) |
| Abstract: | "An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed" |
| Keywords: | Glycerol/metabolism Osmolar Concentration Pheromones/metabolism Phosphoprotein Phosphatases/metabolism Protein Kinases/metabolism Saccharomyces cerevisiae/*cytology/metabolism *Signal Transduction; |
| Notes: | "MedlineSchultz, J Ferguson, B Sprague, G F Jr eng Review England 1995/02/01 Curr Opin Genet Dev. 1995 Feb; 5(1):31-7. doi: 10.1016/s0959-437x(95)90050-0" |
