| Title: | Vomeroglandin/CRP-Ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: identification and characterization of mouse vomeroglandin |
| Author(s): | Matsushita F; Miyawaki A; Mikoshiba K; |
| Address: | "Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-0071, Japan. fumio@fujita-hu.ac.jp" |
| Journal Title: | Biochem Biophys Res Commun |
| ISSN/ISBN: | 0006-291X (Print) 0006-291X (Linking) |
| Abstract: | "Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain. This domain arrangement is similar to those of rat Ebnerin, human DMBT1, and rabbit hensin. In situ hybridization analysis shows strong expression of vomeroglandin mRNA in the glands of vomeronasal system. Immunological analyses detect both membrane-bound and secreted forms of vomeroglandin. The secreted protein seems to be localized in the lumen of the vomeronasal organ, playing a certain role in the pheromone perception" |
| Keywords: | "Amino Acid Sequence Animals COS Cells Calcium-Binding Proteins Cloning, Molecular Concanavalin A/metabolism DNA-Binding Proteins Digestive System/metabolism Female Gene Library Glycosylation Humans Male Membrane Proteins/metabolism Mice Molecular Sequence;" |
| Notes: | "MedlineMatsushita, F Miyawaki, A Mikoshiba, K eng 2000/02/19 Biochem Biophys Res Commun. 2000 Feb 16; 268(2):275-81. doi: 10.1006/bbrc.2000.2104" |
