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Expert Rev Hematol

Title:		Procalcitonin as a diagnostic marker for infection in sickle cell disease
Author(s):		Maharaj S; Chang S;
Address:		"Department of Internal Medicine, University of Louisville, Louisville, KY, USA. Department of Hematology & Oncology, University of Louisville, Louisville, KY, USA"
Journal Title:		Expert Rev Hematol
Year:		2022
Volume:		20220523
Issue:		6
Page Number:		559 - 564
DOI:		10.1080/17474086.2022.2079490
ISSN/ISBN:		1747-4094 (Electronic) 1747-4094 (Linking)
Abstract:		"BACKGROUND: Patients with sickle cell disease (SCD) are at increased risks of infection. Fever often occurs with vaso-occlusive crisis (VOC), posing a diagnostic challenge in SCD. Procalcitonin (PCT) is an infectious biomarker validated in the general population but with limited data on use in SCD. METHODS: We performed a retrospective single-center study (n = 145) with primary objective of assessing ability of PCT to differentiate infection from VOC in SCD presenting with fever. Subgroups included confirmed bacterial infection (CBI), suspected bacterial infection, viral infection, and VOC. A secondary objective examined the association of PCT with acute chest syndrome. Clinical characteristics and data were collected and analyzed to assess the diagnostic performance of PCT and associated variables. RESULTS: Of the cohort, 16% had CBI and 8% had viral infection. PCT was able to discriminate CBI from viral infection [AUC = 0.89 (95%CI, 0.78-0.99)] and VOC [AUC = 0.87 (95%CI, 0.78-0.97)]. PCT had an association with ACS but poor diagnostic performance [AUC = 0.69 (95% CI, 0.54-0.84)]. CONCLUSION: PCT has utility in distinguishing confirmed bacterial infection from VOC or viral infection and is a promising biomarker when investigating fever in SCD"
Keywords:		"*Anemia, Sickle Cell/complications/diagnosis *Bacterial Infections/complications/diagnosis Biomarkers *Hemoglobinopathies Humans Procalcitonin Retrospective Studies *Volatile Organic Compounds Hemoglobinopathy infection sickle cell disease vaso-occlusive;"
Notes:		"MedlineMaharaj, Satish Chang, Simone eng England 2022/05/18 Expert Rev Hematol. 2022 Jun; 15(6):559-564. doi: 10.1080/17474086.2022.2079490. Epub 2022 May 23"