| Title: | A Multi-Centre Study to Risk Stratify Colorectal Polyp Surveillance Patients Utilising Volatile Organic Compounds and Faecal Immunochemical Test |
| Author(s): | Chandrapalan S; Khasawneh F; Singh B; Lewis S; Turvill J; Persaud K; Arasaradnam RP; |
| Address: | "University Hospital of Coventry and Warwickshire, Coventry CV2 2DX, UK. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. University Hospital of Leicester, Leicester LE3 9QP, UK. University Hospital of Plymouth, Plymouth PL4 8AA, UK. York and Scarborough Teaching Hospitals, York YO31 8HE, UK. Department of Chemical Engineering and Analytical Science, University of Manchester, Manchester M13 9PL, UK. Health, Biological & Experimental Sciences, University of Coventry, Coventry CV1 5FB, UK. School of Health Sciences, University of Leicester, Leicester LE1 7RH, UK" |
| ISSN/ISBN: | 2072-6694 (Print) 2072-6694 (Electronic) 2072-6694 (Linking) |
| Abstract: | "(1) Background: The service capacity for colonoscopy remains constrained, and while efforts are being made to recover elective services, polyp surveillance remains a challenge. (2) Methods: This is a multi-centre study recruiting patients already on polyp surveillance. Stool and urine samples were collected for the faecal immunochemical test (FIT) and volatile organic compounds (VOC) analysis, and all participants then underwent surveillance colonoscopy. (3) Results: The sensitivity and specificity of VOC for the detection of a high-risk finding ((>/=2 premalignant polyps including >/=1 advanced polyp or >/=5 premalignant polyps) were 0.94 (95% CI, 0.88 to 0.98) and 0.69 (95% CI, 0.64 to 0.75) respectively. For FIT, the sensitivity was (>/=10 microg of haemoglobin (Hb) / g faeces) 0.54 (95% CI, 0.43 to 0.65) and the specificity was 0.79 (95% CI, 0.73 to 0.84). The probability reduction for having a high-risk finding following both negative VOC and FIT will be 24% if both tests are applied sequentially. (4) Conclusion: The diagnostic performance of VOC is superior to FIT for the detection of a high-risk finding. The performance further improves when VOC is applied together with FIT sequentially (VOC first and then FIT). VOC alone or the combination of VOC and FIT can be used as a triage tool for patients awaiting colonoscopy within a polyp surveillance population, especially in resource-constrained healthcare systems" |
| Keywords: | faecal immunochemical test high-risk finding non-invasive tests polyp surveillance urinary volatile compounds; |
| Notes: | "PubMed-not-MEDLINEChandrapalan, Subashini Khasawneh, Farah Singh, Baljit Lewis, Stephen Turvill, James Persaud, Krishna Arasaradnam, Ramesh P eng N/A/Bowel Research UK/ Switzerland 2022/10/15 Cancers (Basel). 2022 Oct 9; 14(19):4951. doi: 10.3390/cancers14194951" |
