| Title: | Revealing the Mechanisms for Linalool Antifungal Activity against Fusarium oxysporum and Its Efficient Control of Fusarium Wilt in Tomato Plants |
| Author(s): | Li X; Wang Q; Li H; Wang X; Zhang R; Yang X; Jiang Q; Shi Q; |
| Address: | "College of Horticultural Science and Engineering, Shandong Agricultural University, Tai'an 271018, China" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Fusarium oxysporum f. sp. radicis-lycopersici (Forl) is a destructive soil-borne phytopathogenic fungus that causes Fusarium crown and root rot (FCRR) of tomato, leading to considerable field yield losses. In this study, we explored the antifungal capability of linalool, a natural plant volatile organic component, against Forl and its role in controlling FCRR symptoms in tomatoes. Our results showed that Forl mycelial growth was inhibited by the linalool treatment and that the linalool treatment damaged cell membrane integrity, enhanced reactive oxygen species levels, depleted glutathione, and reduced the activities of many antioxidant enzymes in Forl. Transcriptomic and proteomic analyses demonstrated that linalool also downregulated metabolic biosynthetic pathways at the transcript and protein levels, including redox, transporter activity, and carbohydrate metabolism in Forl. Moreover, linalool significantly decreased the expression of many Forl pathogenic genes, such as cell wall degrading enzymes (CWDEs) and G proteins, which is likely how a Forl infection was prevented. Importantly, exogenously applied linalool activated the salicylic acid (SA) and jasmonic acid (JA) defensive pathways to improve disease resistance and relieved the negative effects of Forl on plant growth. Taken together, we report that linalool is an effective fungicide against Forl and will be a promising green chemical agent for controlling FCRR" |
| Keywords: | Antifungal Agents/pharmacology *Fusarium *Solanum lycopersicum Proteomics Plant Diseases/microbiology Fusarium crown and root rot Fusarium oxysporum f.sp.radicis-lycopersici antifungal mechanism transcriptomic and proteomic volatile compounds; |
| Notes: | "MedlineLi, Xiuming Wang, Qifang Li, Haosen Wang, Xiaoyun Zhang, Ruimin Yang, Xiaoyu Jiang, Qiwei Shi, Qinghua eng 2018YFD1000800/National Key Research and Development Program of China/ U1906205, 31872954/National Natural Science Foundation of China/ SDAIT-05/Shandong Vegetable Research System/ 2020LYXZ001/Major Agricultural Application Technology Innovation Project of Shandong Province (2018), and the Key Research and Development Program of Shandong and Chongqing Cooperation/ 2022TZXD0025/Key Research and Development Program of Shandong Province/ Switzerland 2023/01/09 Int J Mol Sci. 2022 Dec 27; 24(1):458. doi: 10.3390/ijms24010458" |
