| Title: | Enterococcal peptide sex pheromones: synthesis and control of biological activity |
| Address: | "Department of Microbiology, University of Minnesota Medical School, 1460 Mayo Bldg., 420 Delaware Street SE, Minneapolis, MN 55455-0312, USA" |
| DOI: | 10.1016/j.peptides.2003.10.020 |
| ISSN/ISBN: | 0196-9781 (Print) 0196-9781 (Linking) |
| Abstract: | "The enterococcal pheromone-inducible plasmids such as pCF10 represent a unique class of mobile genetic elements whose transfer functions are induced by peptide sex pheromones. These pheromones are excreted by potential recipient cells and detected by plasmid-containing donor cells at the cell surface, where the pheromone is imported and signals induction of the plasmid transfer system. Pheromone is processed from a chromosomally encoded lipoprotein and excreted by both the donor and recipient cells, but a carefully controlled detection system prevents a response to self-pheromone while still allowing an extremely sensitive response to exogenous pheromone" |
| Keywords: | "Amino Acid Sequence Animals Bacterial Proteins/chemistry Binding Sites Enterococcus/*metabolism Enterococcus faecalis/metabolism Lipoproteins/chemistry Models, Biological Models, Genetic Molecular Sequence Data Operon Peptides/chemistry Pheromones/chemist;" |
| Notes: | "MedlineChandler, Josephine R Dunny, Gary M eng GM49530/GM/NIGMS NIH HHS/ T32 DE07288/DE/NIDCR NIH HHS/ Research Support, U.S. Gov't, P.H.S. Review 2004/09/18 Peptides. 2004 Sep; 25(9):1377-88. doi: 10.1016/j.peptides.2003.10.020" |
