| Title: | Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes |
| Author(s): | Lammi C; Mulinacci N; Cecchi L; Bellumori M; Bollati C; Bartolomei M; Franchini C; Clodoveo ML; Corbo F; Arnoldi A; |
| Address: | "Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy. Department of Neuroscience, Psychology, Drug and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Florence, Italy. Department of Pharmacy-Pharmaceutical Sciences, University Aldo Moro Bari, 70125 Bari, Italy. Interdisciplinary Department of Medicine, University Aldo Moro Bari, 70125 Bari, Italy" |
| ISSN/ISBN: | 2076-3921 (Print) 2076-3921 (Electronic) 2076-3921 (Linking) |
| Abstract: | "This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic compounds compositions and phenolic profiles were very similar, showing that, while increasing the extraction yields, the innovative process does not change these features. The antioxidant and hypocholesterolemic activities of the extra virgin olive oil (EVOO) phenol extracts were also preserved, since OMU and OMN had equivalent abilities to scavenge the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals in vitro and to protect HepG2 cells from oxidative stress induced by H(2)O(2), reducing intracellular reactive oxygen species (ROS) and lipid peroxidation levels. In addition, by inhibiting 3-hydroxy-3-methylglutarylcoenzyme a reductase, both samples modulated the low-density lipoprotein receptor (LDLR) pathway leading to increased LDLR protein levels and activity" |
| Keywords: | EVOO extract HepG2 cells IOC methods Ldlr Pcsk9 antioxidant;Neuroscience; |
| Notes: | "PubMed-not-MEDLINELammi, Carmen Mulinacci, Nadia Cecchi, Lorenzo Bellumori, Maria Bollati, Carlotta Bartolomei, Martina Franchini, Carlo Clodoveo, Maria Lisa Corbo, Filomena Arnoldi, Anna eng Switzerland 2020/09/02 Antioxidants (Basel). 2020 Aug 27; 9(9):798. doi: 10.3390/antiox9090798" |
