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Mol Microbiol

Title:		The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe
Author(s):		Ladds G; Rasmussen EM; Young T; Nielsen O; Davey J;
Address:		"School of Biochemistry, University of Birmingham, UK"
Journal Title:		Mol Microbiol
Year:		1996
Volume:		20
Issue:		1
Page Number:		35 - 42
DOI:		10.1111/j.1365-2958.1996.tb02486.x
ISSN/ISBN:		0950-382X (Print) 0950-382X (Linking)
Abstract:		"Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P. Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue"
Keywords:		"Carboxypeptidases/*metabolism Gene Expression Regulation, Fungal *Genes, Fungal *Genes, Mating Type, Fungal Hydrogen-Ion Concentration Pheromones/*metabolism/pharmacology Schizosaccharomyces/genetics/*metabolism Schizosaccharomyces pombe Proteins Temperat;"
Notes:		"MedlineLadds, G Rasmussen, E M Young, T Nielsen, O Davey, J eng Research Support, Non-U.S. Gov't England 1996/04/01 Mol Microbiol. 1996 Apr; 20(1):35-42. doi: 10.1111/j.1365-2958.1996.tb02486.x"