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Sensors (Basel)

Title:		Vacuum Ultraviolet Absorption Spectroscopy Analysis of Breath Acetone Using a Hollow Optical Fiber Gas Cell
Author(s):		Kudo Y; Kino S; Matsuura Y;
Address:		"Graduate School of Biomedical Engineering, Tohoku University, 6-6-05 Aoba, Sendai 980-8579, Japan"
Journal Title:		Sensors (Basel)
Year:		2021
Volume:		20210112
Issue:		2
Page Number:		-
DOI:		10.3390/s21020478
ISSN/ISBN:		1424-8220 (Electronic) 1424-8220 (Linking)
Abstract:		"Human breath is a biomarker of body fat metabolism and can be used to diagnose various diseases, such as diabetes. As such, in this paper, a vacuum ultraviolet (VUV) spectroscopy system is proposed to measure the acetone in exhaled human breath. A strong absorption acetone peak at 195 nm is detected using a simple system consisting of a deuterium lamp source, a hollow-core fiber gas cell, and a fiber-coupled compact spectrometer corresponding to the VUV region. The hollow-core fiber functions both as a long-path and an extremely small-volume gas cell; it enables us to sensitively measure the trace components of exhaled breath. For breath analysis, we apply multiple regression analysis using the absorption spectra of oxygen, water, and acetone standard gas as explanatory variables to quantitate the concentration of acetone in breath. Based on human breath, we apply the standard addition method to obtain the measurement accuracy. The results suggest that the standard deviation is 0.074 ppm for healthy human breath with an acetone concentration of around 0.8 ppm and a precision of 0.026 ppm. We also monitor body fat burn based on breath acetone and confirm that breath acetone increases after exercise because it is a volatile byproduct of lipolysis"
Keywords:		"Acetone/*analysis Adipose Tissue/metabolism Breath Tests/instrumentation/*methods Equipment Design Exercise Healthy Volunteers Humans Monitoring, Physiologic/instrumentation/methods Optical Fibers Regression Analysis Sensitivity and Specificity Spectropho;"
Notes:		"MedlineKudo, Yudai Kino, Saiko Matsuura, Yuji eng JP 20H00231/Japan Society for the Promotion of Science/ JP 20K12615/Japan Society for the Promotion of Science/ Switzerland 2021/01/16 Sensors (Basel). 2021 Jan 12; 21(2):478. doi: 10.3390/s21020478"