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Arch Environ Health

Title:		Sensory irritating potency of some microbial volatile organic compounds (MVOCs) and a mixture of five MVOCs
Author(s):		Korpi A; Kasanen JP; Alarie Y; Kosma VM; Pasanen AL;
Address:		"Department of Environmental Sciences, University of Kuopio, Finland"
Journal Title:		Arch Environ Health
Year:		1999
Volume:		54
Issue:		5
Page Number:		347 - 352
DOI:		10.1080/00039899909602499
ISSN/ISBN:		0003-9896 (Print) 0003-9896 (Linking)
Abstract:		"The authors investigated the ability/potencies of 3 microbial volatile organic compounds and a mixture of 5 microbial volatile organic compounds to cause eye and upper respiratory tract irritation (i.e., sensory irritation), with an animal bioassay. The authors estimated potencies by determining the concentration capable of decreasing the respiratory frequency of mice by 50% (i.e., the RD50 value). The RD50 values for 1-octen-3-ol, 3-octanol, and 3-octanone were 182 mg/m3 (35 ppm), 1359 mg/m3 (256 ppm), and 17586 mg/m3 (3360 ppm), respectively. Recommended indoor air levels calculated from the individual RD50 values for 1-octen-3-ol, 3-octanol, and 3-octanone were 100, 1000, and 13000 microg/m3, respectively-values considerably higher than the reported measured indoor air levels for these compounds. The RD50 value for a mixture of 5 microbial volatile organic compounds was also determined and found to be 3.6 times lower than estimated from the fractional concentrations and the respective RD50s of the individual components. The data support the conclusion that a variety of microbial volatile organic compounds may have some synergistic effects for the sensory irritation response, which constrains the interpretation and application of recommended indoor air levels of individual microbial volatile organic compounds. The results also showed that if a particular component of a mixture was much more potent than the other components, it may dominate the sensory irritation effect. With respect to irritation symptoms reported in moldy houses, the results of this study indicate that the contribution of microbial volatile organic compounds to these symptoms seems less than previously supposed"
Keywords:		"Air Microbiology Air Pollutants/*adverse effects *Air Pollution, Indoor Animals Biological Assay Dose-Response Relationship, Drug Eye Diseases/*chemically induced Fungi/metabolism Irritants/adverse effects Ketones/adverse effects Male Mice Octanols/advers;"
Notes:		"MedlineKorpi, A Kasanen, J P Alarie, Y Kosma, V M Pasanen, A L eng Research Support, Non-U.S. Gov't 1999/09/29 Arch Environ Health. 1999 Sep-Oct; 54(5):347-52. doi: 10.1080/00039899909602499"