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J Biomed Opt

Title:		Screening of patients with bronchopulmonary diseases using methods of infrared laser photoacoustic spectroscopy and principal component analysis
Author(s):		Kistenev YV; Karapuzikov AI; Kostyukova NY; Starikova MK; Boyko AA; Bukreeva EB; Bulanova AA; Kolker DB; Kuzmin DA; Zenov KG; Karapuzikov AA;
Address:		"Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, RussiabTomsk State University, University Administration, 36 Lenina Avenue, Tomsk 634050, Russia. Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, Russia. Siberian State Medical University, Medico-Biological Faculty, Physics Department, Moscowski Trakt 2, Tomsk 634050, Russia. Special Technologies Ltd., Zeljonaja Gorka Street 1/3, Novosibirsk 630060, RussiadNovosibirsk State University, 2 Pirogova Street, Novosibirsk 630090, Russia"
Journal Title:		J Biomed Opt
Year:		2015
Volume:		20
Issue:		6
Page Number:		65001 -
DOI:		10.1117/1.JBO.20.6.065001
ISSN/ISBN:		1560-2281 (Electronic) 1083-3668 (Linking)
Abstract:		"A human exhaled air analysis by means of infrared (IR) laser photoacoustic spectroscopy is presented. Eleven healthy nonsmoking volunteers (control group) and seven patients with chronic obstructive pulmonary disease (COPD, target group) were involved in the study. The principal component analysis method was used to select the most informative ranges of the absorption spectra of patients' exhaled air in terms of the separation of the studied groups. It is shown that the data of the profiles of exhaled air absorption spectrum in the informative ranges allow identifying COPD patients in comparison to the control group"
Keywords:		"Adult Breath Tests/*methods Humans Male Middle Aged Photoacoustic Techniques/*methods Principal Component Analysis/*methods Pulmonary Disease, Chronic Obstructive/*diagnosis/metabolism Spectrophotometry, Infrared/*methods Volatile Organic Compounds/analys;"
Notes:		"MedlineKistenev, Yury V Karapuzikov, Alexander I Kostyukova, Nadezhda Yu Starikova, Marina K Boyko, Andrey A Bukreeva, Ekaterina B Bulanova, Anna A Kolker, Dmitry B Kuzmin, Dmitry A Zenov, Konstantin G Karapuzikov, Alexey A eng Research Support, Non-U.S. Gov't 2015/06/04 J Biomed Opt. 2015 Jun; 20(6):065001. doi: 10.1117/1.JBO.20.6.065001"