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Learn Mem

Title:		Visual input regulates circuit configuration in courtship conditioning of Drosophila melanogaster
Author(s):		Joiner MA; Griffith LC;
Address:		"Department of Biology, and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454-9110, USA"
Journal Title:		Learn Mem
Year:		2000
Volume:		7
Issue:		1
Page Number:		32 - 42
DOI:		10.1101/lm.7.1.32
ISSN/ISBN:		1072-0502 (Print) 1072-0502 (Linking)
Abstract:		"Courtship and courtship conditioning are behaviors that are regulated by multiple sensory inputs, including chemosensation and vision. Globally inhibiting CaMKII activity in Drosophila disrupts courtship plasticity while leaving visual and chemosensory perception intact. Light has been shown to modulate CaMKII-dependent memory formation in this paradigm and the circuitry for the nonvisual version of this behavior has been investigated. In this paradigm, volatile and tactile pheromones provide the primary driving force for courtship, and memory formation is dependent upon intact mushroom bodies and parts of the central complex. In the present study, we use the GAL4/UAS binary expression system to define areas of the brain that require CaMKII for modulation of courtship conditioning in the presence of visual, as well as chemosensory, information. Visual input suppressed the ability of mushroom body- and central complex-specific CaMKII inhibition to disrupt memory formation, indicating that the cellular circuitry underlying this behavior can be remodeled by changing the driving sensory modality. These findings suggest that the potential for plasticity in courtship behavior is distributed among multiple biochemically and anatomically distinct cellular circuits"
Keywords:		"Animals Animals, Genetically Modified Brain/enzymology/physiology Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors/metabolism Conditioning, Psychological/drug effects/*physiology Cour;"
Notes:		"MedlineJoiner, M A Griffith, L C eng P01 NS044232/NS/NINDS NIH HHS/ P01 GM 33205/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. 2000/03/08 Learn Mem. 2000 Jan; 7(1):32-42. doi: 10.1101/lm.7.1.32"