| Title: | "Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice" |
| Author(s): | Johanson SM; Ropstad E; Ostby GC; Aleksandersen M; Zamaratskaia G; Boge GS; Halsne R; Trangerud C; Lyche JL; Berntsen HF; Zimmer KE; Verhaegen S; |
| Address: | "Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, As, Norway. Department of Preclinical Sciences and Pathology, Norwegian University of Life Sciences, As, Norway. Department of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, As, Norway. Division of Laboratory Medicine, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway. Department of Paraclinical Sciences, Norwegian University of Life Sciences, As, Norway. National Institute of Occupational Health, Oslo, Norway" |
| DOI: | 10.1371/journal.pone.0252954 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Dams were exposed to the mixture through the diet at Control, Low or High doses (representing 0x, 5000x and 100 000x human estimated daily intake levels, respectively) from weaning and throughout mating, gestation, and lactation. Perinatally exposed female offspring exhibited altered mammary gland development and a suppressed ovarian follicle maturation. Increased hepatic cytochrome P450 enzymatic activities indirectly indicated activation of nuclear receptors and potential generation of reactive products. Hepatocellular hypertrophy was observed from weaning until 30 weeks of age and could potentially lead to hepatotoxicity. Further studies should investigate the effects of human relevant mixtures of POPs on several hormones combined with female reproductive ability and liver function" |
| Keywords: | "Animals Cytochrome P-450 Enzyme System/metabolism Endocrine Disruptors/*toxicity Female Humans Lactation/drug effects Liver/drug effects/*physiology Liver Function Tests Mammary Glands, Animal/drug effects/*growth & development Maternal Exposure/*adverse;" |
| Notes: | "MedlineJohanson, Silje Modahl Ropstad, Erik Ostby, Gunn Charlotte Aleksandersen, Mona Zamaratskaia, Galia Boge, Gudrun Seeberg Halsne, Ruth Trangerud, Cathrine Lyche, Jan Ludvig Berntsen, Hanne Friis Zimmer, Karin Elisabeth Verhaegen, Steven eng Research Support, Non-U.S. Gov't 2021/06/11 PLoS One. 2021 Jun 10; 16(6):e0252954. doi: 10.1371/journal.pone.0252954. eCollection 2021" |
