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J Ethnopharmacol
| Title: | "Sparganii Rhizoma: A review of traditional clinical application, processing, phytochemistry, pharmacology, and toxicity" |
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| Author(s): | Jia J; Li X; Ren X; Liu X; Wang Y; Dong Y; Wang X; Sun S; Xu X; Li X; Song R; Ma J; Yu A; Fan Q; Wei J; Yan X; Wang X; She G; |
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| Address: | "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: jiajia09120912@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: 18343356599@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: renxueyang1996@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: liuxiaoyun9699@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangyu19970721@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: 15328226357@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangxiaopingcx@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: SunSiQi1279@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: xux_26@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: lixiaocherish@sina.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: songruolan@126.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: majiamu96@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: yuaxiang1011@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: ki_ki1998@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: Radiant-JJ@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: yanxinbucm@126.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: wangxiuhuan12340@163.com. School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: shegaimei@126.com" |
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| Journal Title: | J Ethnopharmacol |
| Year: | 2021 |
| Volume: | 20201109 |
| Issue: | |
| Page Number: | 113571 - |
| DOI: | 10.1016/j.jep.2020.113571 |
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| ISSN/ISBN: | 1872-7573 (Electronic) 0378-8741 (Linking) |
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| Abstract: | "ETHNOPHARMACOLOGICAL RELEVANCE: Sparganii Rhizoma (SR), a traditional Chinese medicine (TCM), is the rhizome of Sparganium stoloniferum Buch.-Ham. mainly distributed in East Asia. It has been used for eliminating blood stasis, promoting the flow of Qi, removing the retention of undigested food and relieving pain in China for hundreds of years. AIM OF THE REVIEW: This review summarizes comprehensive information in traditional clinical application, processing, phytochemistry, pharmacology, quality control and toxicity of SR, in exploring future scientific and therapeutic potentials. MATERIALS AND METHODS: Pertinent information was systematically collected from several electronic scientific databases (e.g., Web of Science, PubMed, China Knowledge Resource Integrated, Springer, Elsevier, ScienceDirect, and Google Scholar), PhD and MS dissertations, and classic Chinese medical books. RESULTS: SR is a gynecological drug which is often used to treat dysmenorrhea, mass in the abdomen, amenorrhea due to blood stasis, and abdominal distension in TCM. Two kinds of processed products of SR are included in Chinese Pharmacopoeia, which have better pharmacological effects than the crude herb. Approximately 180 compounds have been identified from SR, including phenylpropanoids, flavonoids, anthraquinones, organic acids, alkaloids, steroids, volatile oils, diarylheptanes, etc. The crude extracts and isolated components of SR have been reported to have anti-tumor, antithrombotic, estrogen antagonistic , anti-inflammatory, analgesic, antioxidant, anti organ fibrosis and other pharmacological activities. SR also has reproductive toxicity. CONCLUSIONS: As an important TCM, SR has been demonstrated by modern pharmacological researches to have significant bioactivities, especially on anti-tumor, antithrombotic, and estrogen antagonistic activities. These activities provide prospects for the development of new drugs and therapeutics for future applications. Nevertheless, quality control and evaluation, in-depth pharmacological mechanism, and toxicological effect of SR require further detailed research" |
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| Keywords: | "Animals Antineoplastic Agents, Phytogenic/chemistry/therapeutic use/toxicity Drugs, Chinese Herbal/chemistry/*therapeutic use/toxicity Ethnopharmacology/*methods Fibrinolytic Agents/chemistry/therapeutic use/toxicity Humans Medicine, Chinese Traditional/*;" |
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| Notes: | "MedlineJia, Jia Li, Xiang Ren, Xueyang Liu, Xiaoyun Wang, Yu Dong, Ying Wang, Xiaoping Sun, Siqi Xu, Xiao Li, Xiao Song, Ruolan Ma, Jiamu Yu, Axiang Fan, Qiqi Wei, Jing Yan, Xin Wang, Xiuhuan She, Gaimei eng Review Ireland 2020/11/13 J Ethnopharmacol. 2021 Mar 25; 268:113571. doi: 10.1016/j.jep.2020.113571. Epub 2020 Nov 9" |
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