| Title: | Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages |
| Author(s): | Causeret F; Fayon M; Moreau MX; Ne E; Oleari R; Parras C; Cariboni A; Pierani A; |
| Address: | "Universite Paris Cite, Imagine Institute, Team Genetics and Development of the Cerebral Cortex, Paris, France. Universite Paris Cite, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France. Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy. Sorbonne Universite, UPMC University Paris 06, Inserm U1127, CNRS UMR 7225, GH Pitie-Salpetriere, Institut du Cerveau et de la Moelle Epiniere, ICM, Paris, France" |
| ISSN/ISBN: | 1096-9861 (Electronic) 0021-9967 (Linking) |
| Abstract: | "In vertebrates, the embryonic olfactory epithelium contains progenitors that will give rise to distinct classes of neurons, including olfactory sensory neurons (OSNs; involved in odor detection), vomeronasal sensory neurons (VSNs; responsible for pheromone sensing), and gonadotropin-releasing hormone (GnRH) neurons that control the hypothalamic-pituitary-gonadal axis. Currently, these three neuronal lineages are usually believed to emerge from uniform pools of progenitors. Here, we found that the homeodomain transcription factor Dbx1 is expressed by neurogenic progenitors in the developing and adult mouse olfactory epithelium. We demonstrate that Dbx1 itself is dispensable for neuronal fate specification and global organization of the olfactory sensory system. Using lineage tracing, we characterize the contribution of Dbx1 lineages to OSN, VSN, and GnRH neuron populations and reveal an unexpected degree of diversity. Furthermore, we demonstrate that Dbx1-expressing progenitors remain neurogenic in the absence of the proneural gene Ascl1. Our work therefore points to the existence of distinct neurogenic programs in Dbx1-derived and other olfactory lineages" |
| Keywords: | Mice Animals *Olfactory Mucosa *Olfactory Receptor Neurons/metabolism Transcription Factors/genetics Gene Expression Regulation Gonadotropin-Releasing Hormone/metabolism Homeodomain Proteins/genetics;neuroscience; |
| Notes: | "MedlineCauseret, Frederic Fayon, Maxime Moreau, Matthieu X Ne, Enrico Oleari, Roberto Parras, Carlos Cariboni, Anna Pierani, Alessandra eng Research Support, Non-U.S. Gov't 2023/05/01 J Comp Neurol. 2023 Aug; 531(12):1229-1243. doi: 10.1002/cne.25492. Epub 2023 May 1" |
