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Proc Natl Acad Sci U S A

Title:		Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents
Author(s):		Jemiolo B; Harvey S; Novotny M;
Address:
Journal Title:		Proc Natl Acad Sci U S A
Year:		1986
Volume:		83
Issue:		12
Page Number:		4576 - 4579
DOI:		10.1073/pnas.83.12.4576
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Two volatile constituents of male mouse urine, 2-(sec-butyl)-4,5-dihydrothiazole and dehydro-exo-brevicomin, were synthesized and tested for their ability to induce estrous cycle in female mice (the Whitten effect). The suppression of ovarian cycling activity that resulted from grouping the females was abolished by exposure to normal male urine. The synthetic compounds, when added together in appropriate concentrations to the (previously inactive) urine of castrated males, or even to water, were found to be as effective as normal male urine. The action of the synthetic compounds appears attenuated for singly caged females"
Keywords:		"Animals Bridged Bicyclo Compounds/*pharmacology *Bridged Bicyclo Compounds, Heterocyclic Bridged-Ring Compounds/*pharmacology Crowding *Estrus Female Male Mice Pheromones/pharmacology/*urine Sexual Behavior, Animal/*drug effects Thiazoles/*pharmacology;"
Notes:		"MedlineJemiolo, B Harvey, S Novotny, M eng 1986/06/01 Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4576-9. doi: 10.1073/pnas.83.12.4576"