| Title: | Prospects and Challenges of Volatile Organic Compound Sensors in Human Healthcare |
| Author(s): | Jalal AH; Alam F; Roychoudhury S; Umasankar Y; Pala N; Bhansali S; |
| Address: | "Department of Electrical and Computer Engineering , Florida International University , Miami , Florida 33174 , United States. Biomolecular Sciences Institute , Florida International University , Miami , Florida 33199 , United States" |
| DOI: | 10.1021/acssensors.8b00400 |
| ISSN/ISBN: | 2379-3694 (Electronic) 2379-3694 (Linking) |
| Abstract: | "The chemical signatures of volatile organic compounds (VOCs) in humans can be utilized for point-of-care (POC) diagnosis. Apart from toxic exposure studies, VOCs generated in humans can provide insights into one's healthy and diseased metabolic states, acting as a biomarker for identifying numerous diseases noninvasively. VOC sensors and the technology of e-nose have received significant attention for continuous and selective monitoring of various physiological and pathophysiological conditions of an individual. Noninvasive detection of VOCs is achieved from biomatrices of breath, sweat and saliva. Among these, detection from sweat and saliva can be continuous in real-time. The sensing approaches include optical, chemiresistive and electrochemical techniques. This article provides an overview of such techniques. These, however, have limitations of reliability, precision, selectivity, and stability in continuous monitoring. Such limitations are due to lack of sensor stability and complexity of samples in a multivariate environment, which can lead to false readings. To overcome selectivity barriers, sensor arrays enabling multimodal sensing, have been used with pattern recognition techniques. Stability and precision issues have been addressed through advancements in nanotechnology. The use of various forms of nanomaterial not only enhance sensing performance, but also plays a major role in detection on a miniaturized scale. The rapid growth in medical Internet of Things (IoT) and artificial intelligence paves a pathway for improvements in human theranostics" |
| Keywords: | "Animals Biomarkers/analysis/blood/metabolism/urine Biosensing Techniques/*instrumentation/methods Breath Tests/*instrumentation/methods Chemistry Techniques, Analytical/*instrumentation/methods *Electronic Nose Equipment Design Extracellular Fluid/chemist;" |
| Notes: | "MedlineJalal, Ahmed H Alam, Fahmida Roychoudhury, Sohini Umasankar, Yogeswaran Pala, Nezih Bhansali, Shekhar eng Research Support, Non-U.S. Gov't Review 2018/06/09 ACS Sens. 2018 Jul 27; 3(7):1246-1263. doi: 10.1021/acssensors.8b00400. Epub 2018 Jun 21" |
