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Angew Chem Int Ed Engl

Title:		Using Chemoattractants to Lure Bacteria to Contact-Killing Surfaces
Author(s):		Jain R; Faith NG; Milkowski A; Nelson K; Busche D; Lynn DM; Czuprynski CJ; Abbott NL;
Address:		"Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI, 53706, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA. Department of Animal Sciences, University of Wisconsin-Madison, 1675 Observatory Drive, Madison, WI, 53706, USA. Bemis Company, Inc., 2301 Industrial Drive, Neenah, WI, 54956, USA. Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI, 53706, USA. abbott@engr.wisc.edu"
Journal Title:		Angew Chem Int Ed Engl
Year:		2016
Volume:		20160405
Issue:		19
Page Number:		5698 - 5702
DOI:		10.1002/anie.201510813
ISSN/ISBN:		1521-3773 (Electronic) 1433-7851 (Linking)
Abstract:		"Antimicrobial surfaces with covalently attached biocidal functionalities only kill microbes that come into direct contact with the surfaces (contact-killing surfaces). Herein, the activity of contact-killing surfaces is shown to be enhanced by using gradients in the concentration of soluble chemoattractants (CAs) to attract bacteria to the surfaces. Two natural and nonbiocidal CAs (aspartate and glucose) were used to attract bacteria to model surfaces decorated with quaternary ammonium groups (known to kill bacteria that come into contact with them). These results demonstrate the killing of Escherichia coli and Salmonella typhimurium, two common pathogens, at levels 10- to 20-times greater than that of the native surfaces alone. This approach is general and provides new strategies for the design of active or dynamic contact-killing surfaces with enhanced antimicrobial activities"
Keywords:		Anti-Infective Agents/chemistry/*pharmacology Aspartic Acid/chemistry Chemotactic Factors/*chemistry/pharmacology Escherichia coli/*drug effects Organosilicon Compounds/chemistry Quaternary Ammonium Compounds/chemistry Salmonella typhimurium/*drug effects;
Notes:		"MedlineJain, Rishabh Faith, Nancy G Milkowski, Andrew Nelson, Kevin Busche, David Lynn, David M Czuprynski, Charles J Abbott, Nicholas L eng Research Support, Non-U.S. Gov't Germany 2016/04/10 Angew Chem Int Ed Engl. 2016 May 4; 55(19):5698-702. doi: 10.1002/anie.201510813. Epub 2016 Apr 5"