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PLoS One

Title:		Reproducibility and respiratory function correlates of exhaled breath fingerprint in chronic obstructive pulmonary disease
Author(s):		Incalzi RA; Pennazza G; Scarlata S; Santonico M; Petriaggi M; Chiurco D; Pedone C; D'Amico A;
Address:		"Chair of Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio-Medico University, Rome, Italy"
Journal Title:		PLoS One
Year:		2012
Volume:		20121015
Issue:		10
Page Number:		e45396 -
DOI:		10.1371/journal.pone.0045396
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"BACKGROUND: The electronic nose (e nose) provides distinctive breath fingerprints for selected respiratory diseases. Both reproducibility and respiratory function correlates of breath fingerprint are poorly known. OBJECTIVES: To measure reproducibility of breath fingerprints and to assess their correlates among respiratory function indexes in elderly healthy and COPD subjects. METHOD: 25 subjects (5 COPD patients for each GOLD stage and 5 healthy controls) over 65 years underwent e-nose study through a seven sensor system and respiratory function tests at times 0, 7, and 15 days. Reproducibility of the e nose pattern was computed. The correlation between volatile organic compound (VOC) pattern and respiratory function/clinical parameters was assessed by the Spearman's rho. MEASUREMENTS AND MAIN RESULTS: VOC patterns were highly reproducible within healthy and GOLD 4 COPD subjects, less among GOLD 1-3 patients.VOC patterns significantly correlated with expiratory flows (Spearman's rho ranging from 0.36 for MEF25% and sensor Co-Buti-TPP, to 0.81 for FEV1% and sensor Cu-Buti-TPP p<0.001)), but not with residual volume and total lung capacity. CONCLUSIONS: VOC patterns strictly correlated with expiratory flows. Thus, e nose might conveniently be used to assess COPD severity and, likely, to study phenotypic variability. However, the suboptimal reproducibility within GOLD 1-3 patients should stimulate further research to identify more reproducible breath print patterns"
Keywords:		"Aged *Breath Tests Case-Control Studies Exercise Female Humans Male Pulmonary Disease, Chronic Obstructive/*physiopathology Reproducibility of Results Volatile Organic Compounds/analysis;"
Notes:		"MedlineIncalzi, Raffaele Antonelli Pennazza, Giorgio Scarlata, Simone Santonico, Marco Petriaggi, Massimo Chiurco, Domenica Pedone, Claudio D'Amico, Arnaldo eng 2012/10/19 PLoS One. 2012; 7(10):e45396. doi: 10.1371/journal.pone.0045396. Epub 2012 Oct 15"