| Title: | Volatolomics in healthcare and its advanced detection technology |
| Author(s): | Hu W; Wu W; Jian Y; Haick H; Zhang G; Qian Y; Yuan M; Yao M; |
| Address: | "School of Aerospace Science and Technology, Xidian University, Xi'an, 730107 China. GRID: grid.440736.2. ISNI: 0000 0001 0707 115X Interdisciplinary Research Center of Smart Sensors, School of Advanced Materials and Nanotechnology, Xidian University, Xi'an, 730107 China. GRID: grid.440736.2. ISNI: 0000 0001 0707 115X Faculty of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, 3200002 Israel. GRID: grid.6451.6. ISNI: 0000000121102151 Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061 China. GRID: grid.452438.c. ISNI: 0000 0004 1760 8119 Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006 China. GRID: grid.13402.34. ISNI: 0000 0004 1759 700X The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033 China. GRID: grid.12981.33. ISNI: 0000 0001 2360 039X State Key Laboratory of Multi-phase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 310006 China. GRID: grid.9227.e. ISNI: 0000000119573309 Institute for Integrated Cell-Material Sciences, Kyoto University Institute for Advanced Study, Kyoto University, Kyoto, 606-8501 Japan. GRID: grid.258799.8. ISNI: 0000 0004 0372 2033" |
| DOI: | 10.1007/s12274-022-4459-3 |
| ISSN/ISBN: | 1998-0124 (Print) 1998-0000 (Electronic) 1998-0000 (Linking) |
| Abstract: | "Various diseases increasingly challenge the health status and life quality of human beings. Volatolome emitted from patients has been considered as a potential family of markers, volatolomics, for diagnosis/screening. There are two fundamental issues of volatolomics in healthcare. On one hand, the solid relationship between the volatolome and specific diseases needs to be clarified and verified. On the other hand, effective methods should be explored for the precise detection of volatolome. Several comprehensive review articles had been published in this field. However, a timely and systematical summary and elaboration is still desired. In this review article, the research methodology of volatolomics in healthcare is critically considered and given out, at first. Then, the sets of volatolome according to specific diseases through different body sources and the analytical instruments for their identifications are systematically summarized. Thirdly, the advanced electronic nose and photonic nose technologies for volatile organic compounds (VOCs) detection are well introduced. The existed obstacles and future perspectives are deeply thought and discussed. This article could give a good guidance to researchers in this interdisciplinary field, not only understanding the cutting-edge detection technologies for doctors (medicinal background), but also making reference to clarify the choice of aimed VOCs during the sensor research for chemists, materials scientists, electronics engineers, etc" |
| Keywords: | artificial olfaction disease diagnosis electronic nose sensor volatile organic compounds volatolomics; |
| Notes: | "PubMed-not-MEDLINEHu, Wenwen Wu, Weiwei Jian, Yingying Haick, Hossam Zhang, Guangjian Qian, Yun Yuan, Miaomiao Yao, Mingshui eng Review China 2022/07/06 Nano Res. 2022; 15(9):8185-8213. doi: 10.1007/s12274-022-4459-3. Epub 2022 Jun 29" |
