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Sci STKE

Title:		Propping up our knowledge of G protein signaling pathways: diverse functions of putative noncanonical Gbeta subunits in fungi
Author(s):		Hoffman CS;
Address:		"Biology Department, Boston College, Chestnut Hill, MA 02467, USA. hoffmacs@bc.edu"
Journal Title:		Sci STKE
Year:		2007
Volume:		20070123
Issue:		370
Page Number:		e3 -
DOI:		10.1126/stke.3702007pe3
ISSN/ISBN:		1525-8882 (Electronic) 1525-8882 (Linking)
Abstract:		"Heterotrimeric guanine nucleotide-binding proteins, composed of Galpha, Gbeta, and Ggamma subunits, are important mediators of fungal pheromone and nutrient signaling pathways. Most fungal genomes encode two or three functionally distinct Galpha subunits but only a single canonical Gbeta subunit, which does not bind multiple Galpha subunits. Studies in Saccharomyces cerevisiae, Cryptococcus neoformans, and Schizosaccharomyces pombe have identified binding partners for Galpha subunits, which are proposed to be 'noncanonical Gbeta subunits.' This Perspective reviews these studies, summarizing the strengths and weaknesses of the claims to this designation for these four fungal proteins"
Keywords:		"Fungal Proteins/*chemistry/metabolism GTP-Binding Protein beta Subunits/*chemistry/physiology GTP-Binding Proteins/*chemistry/metabolism Models, Molecular Protein Structure, Tertiary *Signal Transduction Yeasts/*chemistry;"
Notes:		"MedlineHoffman, Charles S eng R01 GM046226-09/GM/NIGMS NIH HHS/ R01 GM046226-11/GM/NIGMS NIH HHS/ R01 GM046226-12/GM/NIGMS NIH HHS/ R01 GM046226-10A1/GM/NIGMS NIH HHS/ R01 GM046226-13/GM/NIGMS NIH HHS/ R01 GM046226/GM/NIGMS NIH HHS/ R01 GM046226-13S1/GM/NIGMS NIH HHS/ 2007/01/25 Sci STKE. 2007 Jan 23; 2007(370):pe3. doi: 10.1126/stke.3702007pe3"