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Br J Nutr

Title:		Weaning affects lipoprotein lipase activity and gene expression in adipose tissues and in masseter but not in other muscles of the calf
Author(s):		Hocquette JF; Graulet B; Vermorel M; Bauchart D;
Address:		"Unite de Recherches sur les Herbivores, Institut National de la Recherche Agronomique, Centre de Recherches de Clermont Ferrand-Theix, 63122 Saint-Genes-Champanelle, France. hocquet@clermont.inra.fr"
Journal Title:		Br J Nutr
Year:		2001
Volume:		86
Issue:		4
Page Number:		433 - 441
DOI:		10.1079/bjn2001432
ISSN/ISBN:		0007-1145 (Print) 0007-1145 (Linking)
Abstract:		"The nutritional and physiological modifications that occur during the weaning period induce adaptations of tissue metabolism in all mammal species. Among the adaptations due to weaning in ruminants, the regulation of lipoprotein lipase (LPL) activity, one of the rate-limiting steps of fatty acid utilization by tissues, was still unknown. The present study aimed at comparing LPL activity and gene expression in the heart, seven skeletal muscles and three adipose tissue sites between two groups of seven preruminant (PR) or ruminant (R) calves having a similar age (170 d), similar empty body weight (194 kg) at slaughter, and similar net energy intake from birth onwards. Triacylglycerol content of adipose tissues was 16 % lower in R than in PR calves, This could be partly the result from a lower LPL activity (-57 %, ). LPL mRNA levels were also lower in R calves (-48 % to -68 %, ) suggesting a pretranslational regulation of LPL activity. Activity and mRNA levels of LPL did not differ significantly in the heart and skeletal muscles except in the masseter in which LPL activity and mRNA levels were higher (+50 % and +120 % respectively, ) in the R calves. Regulation of LPL in masseter could be explained by the high contractile activity of this muscle after weaning due to solid food chewing. In conclusion, weaning in the calf affects LPL activity and expression in adipose tissues, but not in skeletal muscles except the masseter"
Keywords:		"Adipose Tissue/*enzymology/metabolism *Animal Nutritional Physiological Phenomena Animals Cattle DNA/analysis Fatty Acids, Nonesterified/blood Gene Expression In Situ Hybridization/methods Insulin/blood Lipoprotein Lipase/genetics/*metabolism Male Massete;"
Notes:		"MedlineHocquette, J F Graulet, B Vermorel, M Bauchart, D eng England 2001/10/10 Br J Nutr. 2001 Oct; 86(4):433-41. doi: 10.1079/bjn2001432"